Home >> Signaling Pathways >> MAPK Signaling >> KLF

KLF(Krüppel样因子)

Krüppel-like factor (KLF) family members share a three C2H2 zinc finger DNA binding domain, and are involved in cell proliferation and differentiation control in normal as in pathological situations. KLFs can be deregulated in multiple cancers either by loss of heterozygosity (LOH), somatic mutation or transcriptional silencing by promoter hypermethylation.

KLF family member proteins play a critical role in the growth and metastasis of numerous tumor types, at least in part by regulating the expression of cell cycle genes. Globally, KLF4 and KLF6 are considered as tumor suppressor gene, whereas KLF5 promotes cell proliferation. Family members have different transcriptional properties and can modulate each other's activity by a variety of mechanisms. Since cells can express multiple KLFs, KLF transcription factors build likely a transcriptional network to control cell proliferation. Effects of changes in KLF factors are context-dependent and can appear contradictory, considering differences in the expression profile of family members in various cells. Last, KLF variants may antagonize the function of wild type proteins.

Products for  KLF

  1. Cat.No. 产品名称 Information
  2. GC64287 SR15006 SR15006 是 Kruppel-like factor 5 (KLF5) 的抑制剂剂 (在 DLD-1 CRC 细胞的中,IC50 = 41.6 nM)。
  3. GC32692 APTO-253 (LOR-253) APTO-253 (LOR-253) (LOR-253) 是一种小分子,可抑制 c-Myc 表达,稳定 G-四链体 DNA,并诱导急性髓性白血病细胞的细胞周期停滞和凋亡。
  4. GC11307 ML-264 A selective KLF5 inhibitor

3 Item(s)

per page

Set Descending Direction