MAPK Signaling

Cat.No. Product Name Information

GC48920 β-Carboline-1-carboxylic Acid

GC41656 (±)2-(14,15-Epoxyeicosatrienoyl) Glycerol 2-Arachidonoyl glycerol (2-AG) is an endogenous central cannabinoid (CB1) receptor agonist that is present at relatively high levels in the central nervous system.

GC60393 (-)-Zuonin A (-)-ZuoninA(D-Epigalbacin)是一种天然木质素，是有效的、选择性的JNKs抑制剂，对JNK1、JNK2和JNK3作用的IC50值分别为1.7μM,2.9μM和1.74μM。

GC13944 (5Z)-7-Oxozeaenol

TAK1 mitogen-activated protein kinase kinase kinase (MAPKKK) inhibitor

GC41740 (S)-p38 MAPK Inhibitor III (S)-p38 MAPK inhibitor III is a methylsulfanylimidazole that inhibits p38 MAP kinase (IC50 = 0.90 μM in vitro).

GC12851 10Z-Hymenialdisine Pan kinase inhibitor

GC46554 2'-O-Monosuccinyladenosine-3',5'-cyclic monophosphate

GC39325 2,5-Dihydroxyacetophenone 2,5-Dihydroxyacetophenone 是从熟地黄中分离出的，可通过阻断 ERK1/2 和 NF-κB 信号通路来抑制活化巨噬细胞中炎症介质的产生。

GC35132 4-Hydroxylonchocarpin 4-Hydroxylonchocarpin 是一种查尔酮化合物，来自补骨脂 (Psoralea corylifolia) 提取物。4-Hydroxylonchocarpin 增强 p38 MAPK，JNK 和 ERK 的磷酸化。4-Hydroxylonchocarpin 具有多种药理活性，包括抗菌，抗癌，抗逆转录酶，抗结核，抗疟，抗炎和抗氧化活性。

GC48381 5'-pApA (sodium salt)

GC41423 5-trans Prostaglandin E2 5-trans PGE2 occurs naturally in some gorgonian corals and is a common impurity in commercial lots of PGE1.

GC12834 6-Bnz-cAMP sodium salt cAMP analog,PKA activator

GC42616 7-oxo Staurosporine

7-oxo Staurosporine is an antibiotic originally isolated from S.

GC16929 8-Bromo-cAMP, sodium salt Cell-permeable cAMP analog that activates PKA

GC42622 8-bromo-Cyclic AMP 8-bromo-Cyclic AMP is a brominated derivative of cAMP that remains long-acting due to its resistance to degradation by cAMP phosphodiesterase.

GC15352 8-CPT-Cyclic AMP (sodium salt) lipophilic activator of the cyclic-AMP- and cyclic-GMP-dependent protein kinases, PKA and PKG

GC60037 A-3 hydrochloride A-3 hydrochloride 是靶向多种激酶 (kinase) 的强效、细胞渗透的、可逆的、ATP 竞争性的非选择性拮抗剂。A-3 hydrochloride 是针对 PKA (Ki=4.3 µM)，酪蛋白激酶 II (Ki=5.1 µM) 和肌球蛋白轻链激酶 (MLCK) (Ki=7.4 µM) 的抑制剂。A-3 hydrochloride 还抑制 PKC 和酪蛋白激酶 I 的活性，Ki 分别为 47 µM 和 80 µM。

GA20623 Ac-muramyl-Ala-D-Glu-NH₂ Muramyl dipeptide (MDP) inhibits HIV replication in CD4? H9 lymphocytes..

GC35242 Actein Actein 是从 Cimicifuga foetida 的根茎中分离的三萜糖苷。Actein 通过促进 ROS/JNK 活化和钝化人膀胱癌中的 AKT 途径来抑制细胞增殖，诱导自噬和凋亡。Actein 在体内几乎没有毒性。

GC19019 Acumapimod Acumapimod (BCT197) is an orally active p38 MAP kinase inhibitor, with an IC50 of less than 1 uM for p38α.

Products for MAPK Signaling