MAPK Signaling

Cat.No. Product Name Information

GC13944 (5Z)-7-Oxozeaenol

TAK1 mitogen-activated protein kinase kinase kinase (MAPKKK) inhibitor

GC12851 10Z-Hymenialdisine Pan kinase inhibitor

GC35132 4-Hydroxylonchocarpin 4-Hydroxylonchocarpin 是一种查尔酮化合物，来自补骨脂 (Psoralea corylifolia) 提取物。4-Hydroxylonchocarpin 增强 p38 MAPK，JNK 和 ERK 的磷酸化。4-Hydroxylonchocarpin 具有多种药理活性，包括抗菌，抗癌，抗逆转录酶，抗结核，抗疟，抗炎和抗氧化活性。

GC12834 6-Bnz-cAMP sodium salt cAMP analog,PKA activator

GC16929 8-Bromo-cAMP, sodium salt Cell-permeable cAMP analog that activates PKA

GC15352 8-CPT-Cyclic AMP (sodium salt) lipophilic activator of the cyclic-AMP- and cyclic-GMP-dependent protein kinases, PKA and PKG

GC35242 Actein Actein 是从 Cimicifuga foetida 的根茎中分离的三萜糖苷。Actein 通过促进 ROS/JNK 活化和钝化人膀胱癌中的 AKT 途径来抑制细胞增殖，诱导自噬和凋亡。Actein 在体内几乎没有毒性。

GC19019 Acumapimod Acumapimod (BCT197) is an orally active p38 MAP kinase inhibitor, with an IC50 of less than 1 uM for p38α.

GC32797 AD80 AD80是多种激酶的抑制剂，抑制RET，RAF，SRC和S6K活性，但对mTOR的活性明显减弱。

GC10204 AEG 3482 inhibitor of Jun kinase (JNK)-dependent apoptosis

GC17265 AG-126 ERK1 (p44) and ERK2 (p42) inhibitor

GC12646 AL 8697 p38α inhibitor,potent and selective

GC14899 AMG 548 P38α inhibitor,potent and selective

GC38518 AMG-548 dihydrochloride AMG-548 dihydrochloride 是一种有效的，口服有效的，选择性 p38α 抑制剂 (Ki=0.5 nM)，对 p38β 略有选择性 (Ki=36 nM) 并且对 p38γ 和 p38δ 具有 >1000 倍的选择性。AMG-548 dihydrochloride 也有效抑制全血 LPS 刺激的 TNFα (IC50=3 nM)。AMG-548 dihydrochloride 通过直接抑制酪蛋白激酶 1 (Casein kinase 1) 同种型 δ 和 ε 来抑制 Wnt 信号传导。

GC11559 Anisomycin

JNK agonist, potent and specific

GC15240 APS-2-79 KSR-dependent MAPK modulator

GC32692 APTO-253 (LOR-253) APTO-253是一种Kruppel-likefactor4诱导剂，同时可稳定Gquadruplex结构，具有抗癌活性。

GN10063 Arctigenin Anti-inflammatory, antiproliferative

GC12882 AS 602801 Jun Kinase Inhibitor

GC10010 AS601245 c-Jun NH2-terminal protein kinase inhibitor

Products for MAPK Signaling