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MAPK Signaling

Products for  MAPK Signaling

  1. Cat.No. Product Name Information
  2. GC13944 (5Z)-7-Oxozeaenol

    TAK1 mitogen-activated protein kinase kinase kinase (MAPKKK) inhibitor

  3. GC12851 10Z-Hymenialdisine Pan kinase inhibitor
  4. GC35132 4-Hydroxylonchocarpin 4-Hydroxylonchocarpin 是一种查尔酮化合物,来自补骨脂 (Psoralea corylifolia) 提取物。4-Hydroxylonchocarpin 增强 p38 MAPK,JNK 和 ERK 的磷酸化。4-Hydroxylonchocarpin 具有多种药理活性,包括抗菌,抗癌,抗逆转录酶,抗结核,抗疟,抗炎和抗氧化活性。
  5. GC12834 6-Bnz-cAMP sodium salt cAMP analog,PKA activator
  6. GC16929 8-Bromo-cAMP, sodium salt Cell-permeable cAMP analog that activates PKA
  7. GC15352 8-CPT-Cyclic AMP (sodium salt) lipophilic activator of the cyclic-AMP- and cyclic-GMP-dependent protein kinases, PKA and PKG
  8. GC35242 Actein Actein 是从 Cimicifuga foetida 的根茎中分离的三萜糖苷。Actein 通过促进 ROS/JNK 活化和钝化人膀胱癌中的 AKT 途径来抑制细胞增殖,诱导自噬和凋亡。Actein 在体内几乎没有毒性。
  9. GC19019 Acumapimod Acumapimod (BCT197) is an orally active p38 MAP kinase inhibitor, with an IC50 of less than 1 uM for p38α.
  10. GC32797 AD80 AD80是多种激酶的抑制剂,抑制RET,RAF,SRC和S6K活性,但对mTOR的活性明显减弱。
  11. GC10204 AEG 3482 inhibitor of Jun kinase (JNK)-dependent apoptosis
  12. GC17265 AG-126 ERK1 (p44) and ERK2 (p42) inhibitor
  13. GC12646 AL 8697 p38α inhibitor,potent and selective
  14. GC14899 AMG 548 P38α inhibitor,potent and selective
  15. GC38518 AMG-548 dihydrochloride AMG-548 dihydrochloride 是一种有效的,口服有效的,选择性 p38α 抑制剂 (Ki=0.5 nM),对 p38β 略有选择性 (Ki=36 nM) 并且对 p38γ 和 p38δ 具有 >1000 倍的选择性。AMG-548 dihydrochloride 也有效抑制全血 LPS 刺激的 TNFα (IC50=3 nM)。AMG-548 dihydrochloride 通过直接抑制酪蛋白激酶 1 (Casein kinase 1) 同种型 δ 和 ε 来抑制 Wnt 信号传导。
  16. GC11559 Anisomycin

    JNK agonist, potent and specific

  17. GC15240 APS-2-79 KSR-dependent MAPK modulator
  18. GC32692 APTO-253 (LOR-253) APTO-253是一种Kruppel-likefactor4诱导剂,同时可稳定Gquadruplex结构,具有抗癌活性。
  19. GN10063 Arctigenin Anti-inflammatory, antiproliferative
  20. GC12882 AS 602801 Jun Kinase Inhibitor
  21. GC10010 AS601245 c-Jun NH2-terminal protein kinase inhibitor

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