Na+/K+ ATPase(Na+/K+ ATP酶)

Na⁺/K⁺ ATPase (Sodium potassium pump) is a transmembrane protein complex found in all higher eukaryotes acting as a key energy-consuming pump maintaining ionic and osmotic balance in cells. Na⁺/K⁺ ATPase is an emerging cancer target that merits further investigation.

The constant activity of the Na⁺/K⁺-ATPase (NKA, or Na⁺ pump) is essential for re-establishing and maintaining this gradient. In cardiac and vascular smooth muscle the principal isoforms of the NKA are α1 and α2 and their physiological role is controlled both by their unique and independent signalling pathways, and their discrete subcellular distribution.

Products for Na+/K+ ATPase

Cat.No. 产品名称 Information
GC64887 Gitoxin Gitoxin 是 Na+/K+-ATPase 的抑制剂，是Digitoxin 的降解代谢物，因ZOH 基团靠近C-17β 位置，可改善药代动力学和药效学数据。
GC63832 Strophanthidin Strophanthidin 是一种天然的心脏糖苷。Strophanthidin 0.1 和 1 nmol/L 增加 Na+/K+-ATPase 活性，1~100 μ mol/L 抑制 Na+/K+-ATPase 活性，而 Strophanthidin 10 和 100 nmol/L 对 Na+/K+-ATPase活性无影响。Strophanthidin 增加舒张期和收缩期胞内 Ca2+ 浓度。
GC61628 Neriifolin Neriifolin是一种穿透中枢神经系统的强心苷，是一种Na+,K+-ATPase的抑制剂。Neriifolin可靶向beclin1，抑制LC3相关吞噬体的形成，改善实验性自身免疫性脑脊髓炎(EAE)的发展。Neriifolin诱导人肝癌HepG2细胞周期阻滞和凋亡。
GC61345 Transdermal Peptide Disulfide TFA TransdermalPeptideDisulfideTFA(TD1Disulfide(peptide)TFA)是由11个氨基酸组成的多肽，可以与Na+/K+-ATPasebeta-subunit(ATP1B1)结合，主要与ATP1B1的C末端相互作用。TransdermalPeptideDisulfideTFA能够增强一些大分子在皮肤中的传递。
GC38903 Deslanoside A cardiac glycoside
GC38869 Transdermal Peptide TFA Transdermal Peptide TFA (TD 1 peptide TFA) 是由 11 个氨基酸组成的多肽，可以与 Na+/K+-ATPase beta-subunit (ATP1B1) 结合，主要与 ATP1B1 的 C 末端相互作用。Transdermal Peptide TFA 能够增强一些大分子在皮肤中的传递。
GC41514 Citreoviridin A mycotoxin that inhibits the mitochondrial ATPase
GC19522 Sodium oleate A monounsaturated fatty acid
GC34013 Digitoxin A cardiac glycoside with diverse biological activities
GC32130 (+)-SJ733 (SJ000557733)
(+)-SJ733 (SJ000557733) 是一种抗疟疾药物，还可以抑制 Na+-ATPase PfATP4。
GC30927 Acevaltrate Acevaltrate, an active component derived from the herbal plant Valeriana jatamansi Jones, is strikingly potent to induce GBM cell apoptosis. Acevaltrate inhibits the Na+/K+-ATPase activity in the rat kidney and brain hemispheres with IC50 of 22.8 μM and 42.3 μM, respectively.
GC30535 Transdermal Peptide (TD 1 (peptide)) Transdermal Peptide（TD 1（肽））由11个氨基酸组成，是第一个通过噬菌体展示发现的透皮增强肽。
GC30110 Oleic acid (9-cis-Octadecenoic acid)
油酸（9-顺式-十八碳烯酸）是一种丰富的单不饱和脂肪酸。
GC18203 Annonacin A mitochondrial complex I inhibitor
GC18189 Marinobufagenin An α₁ Na⁺/K⁺ ATPase sodium pump inhibitor
GC12413 Rostafuroxin (PST 2238) An endogenous ouabain blocker at the Na⁺/K⁺ ATPase
GC13108 Digoxin
A Na⁺/K⁺-ATPase inhibitor
GC10579 Ouabain Octahydrate Ouabain Octahydrate 是 Na+/K+-ATPase 的抑制剂，用于治疗充血性心力衰竭。
GC17086 Chlorpropamide A first generation sulfonylurea
GC13162 Prilocaine hydrochloride An Analytical Reference Standard
GC15071 Prilocaine An Analytical Reference Standard
GC17786 Istaroxime hydrochloride Istaroxime hydrochloride 是 Na+/K+-ATPase 抑制剂 (IC50=0.11 μM) 和肌质/内质网钙 ATPase 2 (SERCA 2) 激活剂。
GC11448 Istaroxime Istaroxime (PST2744) 是一种有效的 Na+,K+-ATPase 抑制剂，IC50 为 0.11 μM。
GN10144 Oleandrin A glycoside with diverse biological activities
GN10029 Phloridzin An inhibitor of sodium-glucose cotransporters
GN10156 Ginsenoside Rb1 A triterpene saponin with diverse biological activities
GN10365 Bufalin A cardiotonic steroid