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Chloride Channel(氯离子通道)

Chloride channels represent a relatively under-explored target class for drug discovery as elucidation of their identity and physiological roles has lagged behind that of many other drug targets. Chloride channels are involved in a wide range of biological functions, including epithelial fluid secretion, cell-volume regulation, neuroexcitation, smooth-muscle contraction and acidification of intracellular organelles. Mutations in several chloride channels cause human diseases, including cystic fibrosis, macular degeneration, myotonia, kidney stones, renal salt wasting and hyperekplexia. Chloride-channel modulators have potential applications in the treatment of some of these disorders, as well as in secretory diarrhoeas, polycystic kidney disease, osteoporosis and hypertension.

Chloride channel accessory proteins, also known as calcium-activated chloride channel regulators (CLCA proteins), are a family of transmembrane proteins that have been suggested to have a role in chloride conductance in epithelial cells.

Products for  Chloride Channel

  1. Cat.No. 产品名称 Information
  2. GC68663 ANO1-IN-1 ANO1-IN-1 (Compound 9c) 是一种选择性的 ANO1 通道阻断剂,对 ANO1 和 ANO2 的 IC50 值分别为 2.56 μM 和 15.43 μM。ANO1-IN-1 强烈抑制胶质瘤细胞的增殖。
  3. GC65406 T16A(inh)-C01 T16A(inh)-C01 是一种 TMEM16A (ANO1) 抑制剂。T16A(inh)-C01 不干扰钙信号转导,并能阻断TMEM16A 介导的氯离子电流,IC50 为 8.4 μM。
  4. GC63514 Irisolidone Irisolidone 是葛根花中的主要的异黄酮。Irisolidone 具有较强的保肝活性。Irisolidone 对阴离子通道 VRAC 具有高效阻断作用。
  5. GC61186 Picrotoxinin Picrotoxinin, a potent convulsant, is a chloride channel blocker. Picrotoxinin is a noncompetitive GABAA receptor antagonist, which negatively modulates the action of GABA on GABAAA receptors.
  6. GC60834 Fenamic acid Fenamic acid (N-Phenylanthranilic acid, 2-(Phenylamino)benzoic acid, 2-Anilinobenzoic acid, Diphenylamine-2-carboxylic acid) serves as a parent structure for several nonsteroidal anti-inflammatory drugs (NSAIDs), including mefenamic acid, tolfenamic acid, flufenamic acid, and meclofenamic acid.
  7. GC46086 Ani 9 An inhibitor of ANO1
  8. GC38498 Chlorotoxin (TFA) Chlorotoxin TFA 是从蝎子毒液中分离到的多肽,为氯离子通道 (chloride channel) 阻断剂。Chlorotoxin TFA 具有抗癌作用。
  9. GC34574 Endovion Endovion (NS 3728, SCO-101) is a potent anion channel inhibitor that blocks the Volume Regulated Anion Channels (VRAC).
  10. GC33024 Chlorotoxin Chlorotoxin是从雷蛇属以色列蝎子的毒液中提取的由36个氨基酸组成的肽段,具有抗癌活性。Chlorotoxin是氯离子通道(chloridechannel)阻断剂。
  11. GC31133 NS1652 NS1652是一种可逆的阴离子电导(anionconductance)抑制剂,在人和小鼠的红细胞中,可以抑制氯离子通道(chloridechannel),IC50值为1.6μM。
  12. GC30555 H100 H100是一种氯离子运输(Cl-transport)抑制剂,可以部分抑制氯离子载体NaK2Clcotransporter和Band3anionexchanger,但是对KClcotransporter无作用。
  13. GC19021 Adjudin A derivative of lonidamine
  14. GC18358 MONNA A selective inhibitor of ANO1 A selective inhibitor of ANO1 A selective inhibitor of ANO1
  15. GC15308 IAA-94 A chloride channel inhibitor
  16. GC14768 CaCCinh-A01 A non-selective inhibitor of CaCCs
  17. GC18142 Eact An ANO1 channel activator
  18. GC17930 T16Ainh - A01 An inhibitor of TMEM16A channels
  19. GC14073 DCPIB A VRAC inhibitor
  20. GC14268 NPPB A chloride channel blocker and GPR35 agonist
  21. GC16890 Lubiprostone A ClC-2 activator
  22. GC13466 Flufenamic acid An NSAID and COX inhibitor
  23. GC16564 Niflumic acid A selective COX-2 inhibitor
  24. GC11069 Meticrane Meticrane 是一种利尿剂。
  25. GN10216 Shikonin A natural product with anti-inflammatory and anti-tumor activity

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