Home >> Signaling Pathways >> Membrane Transporter/Ion Channel

Membrane Transporter/Ion Channel

  1. Cat.No. Product Name Information
  2. GC38677 (-)-α-Pinene (-)-α-Pinene 是一种单萜类化合物,通过在 BZD 结合位点作为部分调节剂与 GABAA-苯二氮卓 (BZD) 受体直接结合,显示出增强睡眠的特性。
  3. GC49097 α-Conotoxin AuIB (trifluoroacetate salt) A conotoxin and an antagonist of α3β4 subunit-containing nAChRs
  4. GC49140 α-Conotoxin ImI (trifluoroacetate salt) A conotoxin and an antagonist of α7 nAChRs
  5. GC63269 α-Conotoxin PIA TFA α-Conotoxin PIA TFA 是一种烟碱乙酰胆碱受体 (nAChR) 拮抗剂,靶向包含 α6 和 α3 亚基的 nAChR。α-Conotoxin PIA 具有研究帕金森氏症和精神分裂症的潜力。
  6. GC63723 α-Conotoxin PnIA TFA α-Conotoxin PnIA TFA 是一种有效的选择性哺乳动物 α7nAChR 拮抗剂,具有研究神经性疼痛和阿尔茨海默氏病等神经系统疾病的潜力。
  7. GC10873 α-Spinasterol TRPV1 antagonist
  8. GC63615 α-Thujone α-Thujone 是一种从西方金钟柏精油中分离出来的单萜,具有有效的抗肿瘤活性。α-Thujone 是 GABAA 受体的可逆调节剂,在抑制 GABA 诱导的电流时,α-Thujone 的 IC50 为 21 μM。α-Thujone 诱导 ROS 依赖性细胞毒性,还诱导细胞凋亡 (apoptosis ) 和自噬 (autophagy)。α-Thujone 具有抗伤害,杀虫和驱虫活性,并且很容易穿透血脑屏障。
  9. GC48998 β-Defensin-1 (human) (trifluoroacetate salt) An antimicrobial peptide
  10. GC38010 γ-Aminobutyric acid

    γ-Aminobutyric acid (4-Aminobutyric acid) 是成年哺乳动物大脑中主要的抑制性神经递质,能够与离子移变 GABA 受体 (GABAA) 受体和促代谢受体 (GABAB) 受体结合发挥作用。

  11. GC48313 γ-Lindane
  12. GC15513 ω-Agatoxin IVA P-type calcium channels blocker
  13. GC12608 ω-Agatoxin TK CaV2.1 P/Q-type calcium channels blocker
  14. GC13886 ω-Conotoxin GVIA

    blocker of N-type calcium channels

  15. GC18070 ω-Conotoxin MVIIC wide spectrum blocker of N, P and Q type calcium channels
  16. GC31248 β-Amino Acid Imagabalin Hydrochloride (PD-0332334) β-AminoAcidImagabalinHydrochloride(PD-0332334)是电压依赖性钙离子(calciumchannel)通道的α2δ亚基的配体
  17. GC11449 β-CCB benzodiazepine receptor ligand
  18. GC18033 γDGG glutamate receptor antagonist
  19. GC62067 ω-Conotoxin GVIA TFA

    ω-Conotoxin GVIA TFA 是一种 N 型钙通道 (Ca2+ channel) 抑制剂。

  20. GA24016 ω-Conotoxin MVIIA ω-Conotoxin MVIIA, originally isolated from the venom of the fish-hunting cone snail Conus magus, is a blocker of voltage-sensitive Ca²? channels in neurons. The peptide has been used to identify different Ca²? channel subtypes in amphibian brain.
  21. GC49296 τ-Fluvalinate A pyrethroid acaricide
  22. GC14410 (±)-Epibatidine nicotinic agonist
  23. GC11138 (±)-HIP-A excitatory amino acid transporter (EAAT) blocker
  24. GC13735 (±)-HIP-B excitatory amino acid transporter (EAAT) blocker
  25. GC45985 (±)-Indoxacarb
  26. GC14834 (±)-Nipecotic acid GABA uptake inhibitor
  27. GC41676 (±)-Nornicotine (±)-Nornicotine is a metabolite of nicotine that acts as a neuronal nicotinic acetylcholine receptor (nAChR) agonist.
  28. GC49482 (±)-Nornicotine-d4 An internal standard for the quantification of (±)-nornicotine
  29. GC41677 (±)-SDZ-201 106 (±)-SDZ-201 106 is a diphenylpiperazinylindole derivative that prolongs the open state of cardiac voltage-gated Na+ channels.
  30. GC11982 (±)-threo-3-Methylglutamic acid glutamate transport blocker
  31. GC40466 (±)11(12)-EET

    (±)11(12)-EET is a fully racemic version of the R/S enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes.

  32. GC40434 (±)16-HETE Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites.
  33. GC40270 (±)5(6)-DiHET

    5(6)-DiHET is a fully racemic version of the enantiomeric forms biosynthesized from 5(6)-EET by epoxide hydrolases.

  34. GC40438 (±)5(6)-EET 5(6)-EET is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes.
  35. GN10612 (+)- Praeruptorin C Extracted from Peucedanum praeruptorum Dunn roots;Store the product in sealed, cool and dry condition
  36. GN10745 (+)-Bicuculline GABAA receptor antagonist,competitve and classical
  37. GC34954 (+)-Borneol (+)-Borneol (d-Borneol) 是用于中药镇痛和麻醉的天然双环单萜,增强 GABA 受体活性的 EC50 值为248 μM。
  38. GC30933 (+)-Kavain (+)-Kavain是从卡瓦胡椒(Pipermethysticum)中提取的一种主要的卡瓦内酯,具有抗惊厥作用,通过电压依赖性的Na+和Ca2+通道相互作用,减弱血管平滑肌的收缩。Kavain能与α4β2δGABAA受体结合,加强GABA的功效。Kavain是一种治疗炎症疾病的药物,其抗炎作用已被广泛研究。
  39. GC40808 (+)-Menthol (+)-Menthol is a monoterpene alcohol that has been found in Cannabis and has antifungal activity.
  40. GC16616 (+)-MK 801 Potent NMDA antagonist
  41. GC11025 (+)-MK 801 Maleate Potent NMDA antagonist
  42. GC32130 (+)-SJ733 (SJ000557733) (+)-SJ733是临床上治疗疟疾的候选物,也是一个Na+-ATPasePfATP4抑制剂。
  43. GC34959 (+)-Sparteine (+)-Sparteine 是一种天然生物碱,作为一种神经节阻滞剂。在神经细胞中,(+)-Sparteine 竞争性地抑制烟碱型乙酰胆碱受体 (nACh receptor) 活性。
  44. GC31084 (-)-(S)-B-973B (-)-(S)-B-973B为一种有效的α7nAChR别构激动剂和正别构调节剂,具有镇痛作用。
  45. GC10065 (-)-Bicuculline methiodide GABAA receptor antagonist
  46. GC16857 (-)-Bicuculline methobromide GABAA antagonist
  47. GC15636 (-)-Bicuculline methochloride GABAA antagonist
  48. GC13430 (-)-Blebbistatin Non muscle myosin II ATPase inhibitor
  49. GC63940 (-)-Denudatin B (-)-Denudatin B 具有抗血小板作用,通过电压门控和受体调控的Ca2+通道抑制Ca2+内流,从而放松血管平滑肌。(-)-Denudatin B 通过抑制胶原蛋白和凝血酶诱导的磷酸肌苷分解,在高浓度下具有非特异性的抗血小板作用。
  50. GC14157 (-)-Lobeline hydrochloride nicotinic receptor partial agonist
  51. GC34951 (-)-Menthol (-)-Menthol 是薄荷油的关键成分,(-)-Menthol 结合并激活瞬瞬时受体电位 M8 (TRPM8),TRPM8 是 Ca2+-可渗透的非选择性阳离子通道,最终增加 [Ca2+]i。 具有抗肿瘤活性。

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