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Apoptosis(凋亡)

FKBP (FK506-binding protein) is one of two major immunophilins and most of FKBP family members bind FK506 and show peptidylprolyl cis/trans isomerase (PPIase) activity. Small size FKBP family members contain only FK506-binding domain, while FKBPs with large molecular weights possess extra domains such as tetratricopeptide repeat domains, calmodulin binding and transmembrane motifs. FKBPs are involved in several biochemical processes including protein folding, receptor signaling, protein trafficking and transcription. FKBP family proteins play important functional roles in the T-cell activation, when complexed with their ligands.

FK506-binding proteins 1a and 1b (FKBP1a/1b) are immunophilin proteins that bind the immunosuppressant agent FK506 and AY 22989. FKBP12 is a ubiquitous abundant protein that acts as a receptor for FK506, binds tightly to intracellular calcium release channels and to the transforming growth factor β (TGF-β) type I receptor.

Products for  Apoptosis

  1. Cat.No. 产品名称 Information
  2. GC41183 α-Carotene A precursor of vitamin A
  3. GC45204 α-Ecdysone A prohormone of 20-hydroxy ecdysone
  4. GC63941 α-Solanine α-solanine 是马铃薯中的一种生物活性成分,是主要的甾体类生物碱之一,可抑制癌细胞的生长并诱导其凋亡 (apoptosis)。
  5. GC67618 α-Tocopherol phosphate disodium α-Tocopherol phosphate (alpha-Tocopherol phosphate) 是一种抗氧化剂,可以保护长波 UVA1 诱导的细胞死亡,并清除 UVA1 诱导的活性氧 (ROS)。α-Tocopherol phosphate disodium 可抑制内皮祖细胞凋亡 (apoptosis),增加高糖/低氧条件下内皮祖细胞迁移能力,促进血管生成。
  6. GC41623 β-Elemonic Acid A triterpene with anticancer activity
  7. GC64619 β-Ionone β-Ionone 可有效诱导胃腺癌细胞 SGC7901 凋亡 (apoptosis)。具有抗肿瘤活性。
  8. GC49268 (+)-δ-Cadinene A sesquiterpene with antimicrobial and anticancer activities
  9. GC18516 (+)-Aeroplysinin-1 A sea sponge metabolite with diverse biological activities
  10. GC45274 (+)-Pinoresinol A lignan with diverse biological activities
  11. GC62193 (1S,2S)-Bortezomib (1S,2S)-Bortezomib 是 Bortezomib 的对映异构体。Bortezomib 是一种细胞渗透性、可逆性和选择性的蛋白酶体抑制剂,通过靶向苏氨酸残基有效抑制 20S 蛋白酶体 (Ki 为 0.6 nM)。Bortezomib 破坏细胞周期、诱导细胞凋亡以及抑制核因子 NF-κB。Bortezomib 是一种抗癌药物,也是第一种用于人类的蛋白酶体抑制剂。
  12. GC60397 (5Z,2E)-CU-3 A DGK-α inhibitor
  13. GC60398 (6R)-FR054 (6R)-FR054是FR054的一个活性异构体。FR054是HBP酶PGM3的抑制剂,具有显著的抗乳腺癌活性。FR054可诱导内质网应激和ROS依赖的细胞凋亡。
  14. GA20156 (D-Ser(tBu)⁶,Azagly¹⁰)-LHRH (free base)
  15. GC61437 (E)-Methyl 4-coumarate A phenol with diverse biological activities
  16. GC39281 (R)-CR8 trihydrochloride An inhibitor of cyclin-dependent kinases
  17. GC60407 (R)-Verapamil D7 hydrochloride (R)-VerapamilD7hydrochloride((R)-(+)-VerapamilD7hydrochloride)是(R)-Verapamilhydrochloride的一种氘代化合物。(R)-Verapamilhydrochloride((R)-(+)-Verapamilhydrochloride)是一种P-糖蛋白抑制剂。(R)-Verapamilhydrochloride抑制MRP1介导的转运,导致MRP1过表达细胞对抗癌药产生化学敏感性。
  18. GC60408 (R)-Verapamil hydrochloride (R)-Verapamilhydrochloride((R)-(+)-Verapamilhydrochloride)是一种P-糖蛋白(P-Glycoprotein)抑制剂。(R)-Verapamilhydrochloride抑制MRP1介导的转运,导致MRP1过表达细胞对抗癌药产生化学敏感性。
  19. GC62528 (Rac)-Hesperetin (Rac)-Hesperetin 是Hesperetin 的外消旋体。 Hesperetin 是一种天然黄烷酮类物质,为有效的,广谱的人 UGT 抑制剂。Hesperetin 可通过激活 p38 MAPK 来诱导凋亡。
  20. GC61750 (Rac)-Indoximod (Rac)-Indoximod(1-Methyl-DL-tryptophan)是吲哚胺-2,3-双加氧酶(IDO)抑制剂。(Rac)-Indoximod和IFN-γ联用显著降低了表达α-SMA的人心肌成纤维细胞活性,并通过上调IRF-1,Fas和FasL基因诱导凋亡(apoptosis)。
  21. GC52192 (S)-4'-nitro-Blebbistatin A more stable and less phototoxic form of (–)-blebbistatin
  22. GC60425 (S)-Verapamil D7 hydrochloride (S)-VerapamilD7hydrochloride((S)-(-)-VerapamilD7hydrochloride)是(S)-Verapamilhydrochloride的一种氘代化合物。(S)-Verapamilhydrochloride(S(-)-Verapamilhydrochloride)通过MRP1抑制白三烯C4(LTC4)和钙黄绿素的转运。(S)-Verapamilhydrochloride导致潜在耐药性肿瘤细胞死亡。
  23. GC60008 (S)-Verapamil hydrochloride (S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) 通过 MRP1 抑制白三烯 C4 (LTC4) 和钙黄绿素的转运。(S)-Verapamil hydrochloride 导致潜在耐药性肿瘤细胞死亡。
  24. GC19528 1,4-Benzoquinone A toxic metabolite of benzene
  25. GC35057 14-Deoxyandrographolide A diterpene lactone with diverse biological properties
  26. GC41938 15-Lipoxygenase Inhibitor 1 An inhibitor of 15-LO
  27. GC39296 1G244 1G244 是一种有效的 DPP8/9 抑制剂,IC50 分别为 12 nM 和 84 nM,但不抑制 DPPIV 和 DPPII。1G244 可诱导多发性骨髓瘤细胞凋亡,并具有抗骨髓瘤作用。
  28. GC41612 2'-O-Methylguanosine A modified nucleoside
  29. GC68452 2,4,6-Triiodophenol 2,4,6-Triiodophenol 是一种具有口服活性的、强效的 leukotriene B4 (LTB4) 合成抑制剂。2,4,6-Triiodophenol 可诱导小鼠囊胚凋亡。
  30. GC49223 2-deoxy-D-Glucose-13C6 An internal standard for the quantification of 2-deoxy-D-glucose
  31. GC68043 2-tert-Butyl-1,4-benzoquinone 2-tert-Butyl-1,4-benzoquinone 是 butylated hydroxyanisole 的亲电代谢产物,是 2-tert-butylhydroquinone 的氧化产物。
  32. GC64762 3,6-Dihydroxyflavone 3,6-Dihydroxyflavone 是一种抗癌剂。3,6-Dihydroxyflavone 剂量和时间依赖性地降低细胞活力并通过激活半胱天冬酶级联、切割聚 (ADP-核糖) 聚合酶 (PARP) 诱导 apoptosis。3,6-Dihydroxyflavone 增加细胞内氧化应激和脂质过氧化。
  33. GC49849 3-Aminosalicylic Acid A salicylic acid derivative
  34. GC60507 3-O-Methylgallic acid 3-O-Methylgallicacid(3,4-Dihydroxy-5-methoxybenzoicacid)是一种花青素代谢产物,具有强大的抗氧化能力。3-O-Methylgallicacid能抑制Caco-2细胞增殖,IC50值为24.1μM。3-O-Methylgallicacid还诱导细胞凋亡(apoptosis)并具有抗癌作用。
  35. GC42401 4-hydroperoxy Cyclophosphamide

    An activated analog of cyclophosphamide

  36. GC60525 4-Vinylphenol (10%w/w in propylene glycol)

    4-Vinylphenol存在于药用草白花蛇舌草,野生稻中,也是葡萄酒中乳酸菌对对香豆酸和阿魏酸的代谢产物。4-Vinylphenol诱导凋亡(apoptosis),在体内抑制血管形成并抑制浸润性乳腺肿瘤生长。

  37. GC52227 5-(3',4'-Dihydroxyphenyl)-γ-Valerolactone An active metabolite of various polyphenols
  38. GC68562 5-Aminolevulinic acid-13C-1 hydrochloride 5-Aminolevulinic acid-13C-1 (5-ALA-13C-1) hydrochloride 是 13C 标记的 5-Aminolevulinic acid hydrochloride。5-Aminolevulinic acid hydrochloride (5-ALA hydrochloride) 是体内血红素生物合成的中间体,为四吡咯的前体。
  39. GC49429 6-keto Lithocholic Acid A metabolite of lithocholic acid
  40. GC45673 7,8-Dihydroneopterin An antioxidant
  41. GC60544 A-192621 A-192621是一种有效的非肽,口服活性,选择性内皮素B(ETB)受体拮抗剂,IC50为4.5nM,Ki为8.8nM。A-192621的选择性比ETA高636倍(IC50为4280nM,Ki为5600nM)。A-192621促进PASMC细胞凋亡,并引起动脉血压升高和血浆ET-1水平升高。
  42. GC60548 ABT-100 ABT-100是一种有效的,高选择性和口服活性的farnesyltransferase抑制剂。ABT-100抑制细胞增殖(对于EJ-1,DLD-1,MDA-MB-231,HCT-116,MiaPaCa-2,PC-3和DU-145细胞的IC50分别为2.2nM,3.8nM,5.9nM,6.9nM,9.2nM,70nM和818nM),可增加细胞凋亡并减少血管生成。ABT-100具有广谱抗肿瘤活性。
  43. GC49745 ABT-263-d8 An internal standard for the quantification of ABT-263
  44. GC48470 Ac-DEVD-CHO (trifluoroacetate salt) A dual caspase-3/caspase-7 inhibitor
  45. GC18226 Ac-LEHD-AMC (trifluoroacetate salt) A caspase-9 fluorogenic substrate
  46. GC13400 Ac-VDVAD-AFC A fluorogenic substrate for caspase-2
  47. GC52372 Ac-VDVAD-AFC (trifluoroacetate salt) A fluorogenic substrate for caspase-2
  48. GC48974 Ac-VEID-AMC (ammonium acetate salt) A caspase-6 fluorogenic substrate
  49. GC39584 AGN194204 AGN194204 (IRX4204) 是一种具有口服活性的,选择性 RXR 激动剂,对 RXRα,RXRβ 和 RXRγ 的 Kd 值分别为 0.4 nM,3.6 nM 和 3.8 nM,EC50 分别为 0.2 nM,0.8 nM 和 0.08 nM。AGN194204 对 RAR 无活性,并具有抗炎和抗癌作用。
  50. GC68632 AK-778-XXMU AK-778-XXMU是DNA结合2 (ID2) 拮抗剂的有效抑制剂,KD为129 nM。AK-778-XXMU 能抑制胶质瘤细胞株的迁移和侵袭,诱导细胞凋亡 (apoptosis),更重要的是能减缓肿瘤生长。
  51. GC49773 Albendazole sulfone-d3 An internal standard for the quantification of albendazole sulfone

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