Chromatin/Epigenetics

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

Products for Chromatin/Epigenetics

Cat.No. Product Name Information
GC31365 γ-Oryzanol γ-Oryzanol有效抑制小鼠纹状体中的DNA甲基转移酶(DNMTs)。抑制DNMT1和DNMT3a，IC50分别为3.2μM和22.3μM。
GC34958 (+)-JQ1 PA (+)-JQ1 PA 是溴结构域和额外末端结构域 (BET) 抑制剂 JQ1 的衍生物，其 IC50 值为 10.4 nM。
GC13822 (-)-JQ1
BET bromodomain inhibitor
GC34964 (1S,3R,5R)-PIM447 dihydrochloride (1S,3R,5R)-PIM447 (dihydrochloride)是PIM的抑制剂，来自专利US 20100056576 A1化合物实例72。对Pim1，Pim2和Pim3的IC50分别为0.095，0.522和0.369 μM。
GC34971 (3R,4S)-Tofacitinib Tofacitinib(CP-690550)是高效JAK3抑制剂，IC50为1 nM，比对JAK2和JAK1的抑制性高20倍和100倍。
GC34972 (3S,4R)-Tofacitinib Tofacitinib(CP-690550)是高效JAK3抑制剂，IC50为1 nM，比对JAK2和JAK1的抑制性高20倍和100倍。
GC34973 (3S,4S)-Tofacitinib Tofacitinib(CP-690550)是高效JAK3抑制剂，IC50为1 nM，比对JAK2和JAK1的抑制性高20倍和100倍。
GC15104 (R)-(+)-Etomoxir sodium salt carnitine palmitoyltransferase I (CPT1) inhibitor
GC34443 (R)-BAY1238097 (R)-BAY1238097是BAY1238097的低活性R型异构体。BAY1238097是一种有效的、BET与组蛋白结合的选择性抑制剂，通过下调c-Myc水平及下游转录组，在AML(急性髓性白血病)和MM(多发性骨髓瘤)模型中表现出较强的抗增殖活性。
GC11340 (R)-PFI 2 hydrochloride SETD7 histone lysine methyltransferase inhibitor
GC34446 (rac)-BAY1238097 (rac)-BAY1238097是一种BET抑制剂，对BRD4的IC50值为1.02μM。用于癌症研究。
GC33198 (S)-JQ-35 (TEN-010) (S)-JQ-35(TEN-010)是BET家族的抑制剂，有着潜在的抗肿瘤活性。
GC13634 (S)-PFI-2 (hydrochloride) Negative control of (R)-PFI 2 hydrochloride
GC17055 1,2,3,4,5,6-Hexabromocyclohexane JAK2 tyrosine kinase inhibitor
GC12775 2',3',5'-triacetyl-5-Azacytidine prodrug form of 5-azacytidine, a DNA methyltransferase inhibitor
GC11873 2,4-Pyridinedicarboxylic Acid Histone LSD inhibitor
GC10408 2-D08 Sumoylation inhibitor
GC11249 2-hexyl-4-Pentynoic Acid Potent and robust HDACs inhibitor
GC15084 2-Methoxyestradiol (2-MeOE2)
Apoptotic, antiproliferative and antiangiogenic agent
GC14282 3-acetyl-11-keto-β-Boswellic Acid 5-lipoxygenase inhibitor