Chromatin/Epigenetics

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

Products for Chromatin/Epigenetics

Cat.No. Product Name Information
GC13822 (-)-JQ1
BET bromodomain inhibitor
GC15104 (R)-(+)-Etomoxir sodium salt carnitine palmitoyltransferase I (CPT1) inhibitor
GC11340 (R)-PFI 2 hydrochloride SETD7 histone lysine methyltransferase inhibitor
GC13634 (S)-PFI-2 (hydrochloride) Negative control of (R)-PFI 2 hydrochloride
GC17055 1,2,3,4,5,6-Hexabromocyclohexane JAK2 tyrosine kinase inhibitor
GC12775 2',3',5'-triacetyl-5-Azacytidine prodrug form of 5-azacytidine, a DNA methyltransferase inhibitor
GC11873 2,4-Pyridinedicarboxylic Acid Histone LSD inhibitor
GC10408 2-D08 Sumoylation inhibitor
GC11249 2-hexyl-4-Pentynoic Acid Potent and robust HDACs inhibitor
GC15084 2-Methoxyestradiol (2-MeOE2)
Apoptotic, antiproliferative and antiangiogenic agent
GC17907 3-Deazaneplanocin A (DZNep) hydrochloride SAHH and ENZ2 inhibitor
GC13145 3-Deazaneplanocin,DZNep S-adenosylhomocysteine and EZH2 inhibitor
GC17922 4'-bromo-Resveratrol Sirt1 and Sirt3 inhibitor
GC16474 4-HQN PARP inhibitor
GC17005 4-iodo-SAHA class I and class II histone deacetylase (HDAC) inhibitor
GC12667 4SC-202 Class I HDAC inhibitor
GC10898 5-(N,N-dimethyl)-Amiloride (hydrochloride) NHE1, NHE2, and NHE3 inhibitor
GC10946 5-Azacytidine DNA methyltransferase inhibitor.
GC16015 A 366 G9a/GLP histone lysine methyltransferase inhibitor
GC12390 A-966492 PARP-1/-2 inhibitor, highly potent