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DNA Damage/DNA Repair

  1. Cat.No. Product Name Information
  2. GC19566 N-Nitrosodiethylamine
  3. GC38000 β-Boswellic acid β-Boswellic acid 是从乳香 Boswellia serrate 的树胶脂中分离出来的。β-Boswellic acid 是 5-脂氧合酶 (5-LO) 产物形成的非还原型抑制剂,其直接与 5-LO 相互作用或阻断其易位。β-Boswellic acid 抑制人白血病 HL-60 细胞中 DNA,RNA和蛋白质的合成。
  4. GC31365 γ-Oryzanol γ-Oryzanol有效抑制小鼠纹状体中的DNA甲基转移酶(DNMTs)。抑制DNMT1和DNMT3a,IC50分别为3.2μM和22.3μM。
  5. GC38194 (±)-10-Hydroxycamptothecin (±)-10-Hydroxycamptothecin 是从喜树中分到的生物碱,能够抑制拓扑异构酶 I (topoisomerase I) 的活性,具有广谱的抗肿瘤活性。
  6. GC33107 (±)-BAY-1251152 (±)-BAY-1251152是BAY-1251152的消旋混合物。BAY-1251152是一种有效且高选择性的PTEF/CDK9抑制剂。
  7. GC10867 (+)-Aphidicolin Tetracyclic diterpene antibiotic
  8. GC34955 (+)-CBI-CDPI1 (+)-CBI-CDPI1 是 CC-1065 功能增强的一种类似物。(+)-CBI-CDPI1 是一种 DNA 烷化剂。(+)-CBI-CDPI1 可用作抗体-药物偶联物 (ADCs) 中的毒素分子。
  9. GC34956 (+)-CBI-CDPI2 (+)-CBI-CDPI2 是 CC-1065 功能增强的一种类似物。(+)-CBI-CDPI1 是一种 DNA 烷化剂。(+)-CBI-CDPI2 可用作抗体-药物偶联物 (ADCs) 中的毒素分子。
  10. GC32429 (-)-BAY-1251152 (-)-BAY-1251152是BAY-1251152的一个对映体,旋光性为(-)。BAY-1251152是一种有效且高选择性的细胞周期依赖型蛋白激酶(PTEF/CDK9)的抑制剂。
  11. GC48635 (-)-Cryptopleurine
  12. GC40076 (-)-Voacangarine (-)-Voacangarine is an indole alkaloid originally isolated from V.
  13. GC38377 (2S,3R)-Voruciclib hydrochloride (2S,3R)-Voruciclib hydrochloride 是 Voruciclib hydrochloride 的低活性异构体。Voruciclib hydrochloride 是一种 CDK9 抑制剂。
  14. GC41695 (6R,S)-5,6,7,8-Tetrahydrofolic Acid (hydrochloride) (6R,S)-5,6,7,8-Tetrahydrofolic acid (THFA), the reduced form of folic acid, serves as a cofactor in methyltransferase reactions and is the major one-carbon carrier in one carbon metabolism.
  15. GC41088 (6S)-Tetrahydrofolic Acid (6S)-Tetrahydrofolic acid is a diastereomer of tetrahydrofolic acid, a reduced form of folic acid that serves as a cofactor in methyltransferase reactions and is the major one-carbon carrier in one carbon metabolism.
  16. GC41716 (R)-CR8 Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy.
  17. GC39281 (R)-CR8 trihydrochloride (R)-CR8 trihydrochloride (CR8 trihydrochloride) 是 Roscovitine 的第二代类似物,是一种有效的 CDK1/2/5/7/9 抑制剂。(R)-CR8 trihydrochloride 抑制 CDK1/cyclin B (IC50=0.09 μM)、CDK2/cyclin A (0.072 μM)、CDK2/cyclin E (0.041 μM)、CDK5/p25 (0.11 μM)、CDK7/cyclin H (1.1 μM)、CDK9/cyclin T (0.18 μM) 和 CK1δ/ε (0.4 μM)。(R)-CR8 trihydrochloride 诱导细胞凋亡并具有神经保护作用。
  18. GC34444 (R)-Nedisertib (R)-Nedisertib((R)-M3814)是一种活性较弱的Nedisertib的R型异构体,对DNA-PK的IC50值为7-30nM。
  19. GC41633 (R)-Prunasin (R)-Prunasin is a cyanogenic glucoside that is the precursor to amygdalin, a bitter component found in species of the genera Prunus and Olinia.
  20. GC34124 (rel)-MC180295 (rel)-MC180295是一种有效、选择性的CDK9-CyclinT1抑制剂,IC50值为5nM,对其选择性至少是对其他CDK激酶22倍。(rel)-MC180295同时抑制GSK-3α和GSK-3β。(rel)-MC180295具有的抗肿瘤活性。
  21. GC10098 (S)-10-Hydroxycamptothecin inhibitor of topoisomerase I

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