Arp2/3 Complex(Arp2/3 复合体)
The intact ARP2/3 complex is first purified from Acanthamoeba castellanii based on its affinity for the actin-binding protein profilin, and is shown to consist of a stable assembly of seven polypeptides. Two of the subunits are actin-related proteins of the ARP2 and ARP3 subfamilies, giving the complex its name.
The ARP2/3 complex possesses little biochemical activity on its own. However, when engaged by nucleation-promoting factor (NPF) proteins, it is activated to initiate the formation of a new (daughter) filament that emerges from an existing (mother) filament in a y-branch configuration with a regular 70° branch angle. This coupling of nucleation and branching by the ARP2/3 complex is referred to as autocatalytic branching or dendritic nucleation, and is central to its functions in vivo.
Polymerization of actin filaments directed by the Arp2/3 complex supports many types of cellular movements.
Products for Arp2/3 Complex
- Cat.No. 产品名称 Information
- GC61831 Benproperine phosphate An antitussive agent and ARPC2 inhibitor
- GC14060 CK 666 An Arp2/3 inhibitor
- GC15076 CK 869 An inhibitor of the Arp2/3 complex
- GC15894 CK-636 An inhibitor of Arp2/3 complex action
- GC32890 Cytochalasin B (Phomin) Cytochalasin B(细胞松弛素B)是一种可渗透细胞的真菌毒素,从Phoma属的子囊菌真菌中分离得到[1-2]。
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GC13440
Cytochalasin D
An inhibitor of actin polymerization
- GC43461 Dihydrocytochalasin B An inhibitor of actin assembly and cytokinesis
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GC15671
Latrunculin A
一种可逆抑制肌动蛋白聚合的药物