CaMK(钙调蛋白激酶)
The Ca2+/calmodulin-dependent kinase (CaMK) family has been recognized as a key mediator in living organisms and various biological processes.
Calcium/calmodulin kinase II (CaMK II) is a multifunctional cytoplasmic calcium and calmodulin-dependent protein kinase that phosphorylates and alters the function of a variety of substrates. The CaMK II pathway has been found to regulate the RANKL-induced osteoclast formation via the cAMP-response element binding protein (CREB) pathway.
Among many signaling pathways of proliferation, intracellular calciumol/L has been extensively demonstrated to be very important. In cytoplasm, calciumol/L binds to calmodulin, and then activates the Ca2+/calmodulin (CaM) dependent kinases (CaMKs) which are a family of structurally related serine/threonine protein kinases including CaMKI-IV. CaMKII, a multi functional protein kinase, is ubiquitously involved in many physiological processes including control of cell cycle, apoptosis, gene expression, and neurotransmission.
Products for CaMK
- Cat.No. 产品名称 Information
- GC49440 ML-9 A PKB/Akt inhibitor
- GC62146 XST-14 XST-14 是一种有效的,竞争性强且高度选择性的 ULK1 抑制剂,IC50 为 26.6 nM。XST-14 通过减少 ULK1 下游底物的磷酸化来诱导自噬抑制。XST-14 诱导肝细胞癌 (HCC) 细胞凋亡,并具有抗肿瘤作用。
- GC61521 Calmodulin-Dependent Protein Kinase II(290-309) acetate Calmodulin-DependentProteinKinaseII(290-309)acetate是有效的CaMK拮抗剂,抑制抑制Ca2+/钙调蛋白依赖性蛋白激酶II的IC50值为52nM。
- GC60037 A-3 hydrochloride A-3 hydrochloride, a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases, againsts cAMP-dependent protein kinase (PKA) (Ki=4.3 ?M), casein kinase II (CK2) (Ki=5.1 ?M) and myosin light chain kinase (MLCK) (Ki=7.4 ?M), also inhibits Protein Kinase C (PKC) and casein kinase I (CK1) with Ki values of 47 ?M and 80 ?M, respectively.
- GC50305 Autocamtide-2-related inhibitory peptide, myristoylated Autocamtide-2 相关抑制肽,肉豆蔻酰化是肉豆蔻酰化 Autocamtide-2 相关抑制肽。
- GC37710 Syntide 2 (TFA) A protein kinase substrate
- GC37694 STO-609 A CaMKK inhibitor
- GC35820 DDD107498 succinate DDD107498 (M-5717, DDD-498) is a P. falciparum translation elongation factor 2 inhibitor. DDD107498 exhibits a potent and novel spectrum of antimalarial activity against multiple life-cycle stages of the Plasmodium parasite.
- GC35601 CaMKII-IN-1 CaMKII-IN-1是CaMKII高效选择性抑制剂,IC50值为63nM,对CaMKIV, MLCK, p38a, Akt1,和PKC几乎无作用。
- GC35432 Autocamtide-2-related inhibitory peptide (TFA) A CaMKII inhibitor
- GC34390 Autocamtide 2, amide Autocamtide2,amide是钙调蛋白激酶(CaMK)家族实验的底物(100μMfinalconcentration)。
- GC33775 Rimacalib (SMP 114) Rimacalib (SMP 114) (SMP 114) 是一种 Ca2+/钙调蛋白依赖性蛋白激酶 II (CaMKII) 抑制剂,IC50 为 ~1 μ;M 代表 CaMKIIα;至 ~30 μ;M 代表 CaMKIIγ;。
- GC33732 Syntide 2 A protein kinase substrate
- GC33683 Autocamtide 2 (Autocamtide II) Autocamtide 2 (Autocamtide II) 是钙/钙调蛋白依赖性蛋白激酶 II (CaMKII) 的高选择性肽底物。
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GC31170
Calmodulin-Dependent Protein Kinase II 290-309
A CaMKII inhibitor
- GC30356 Metofenazate (Methophenazine) Metofenazate (Methophenazine) 是一种选择性钙调蛋白抑制剂。
- GC12804 KN-93 Phosphate A CaMKII inhibitor
- GC12739 A 484954 An eEF-2K inhibitor
- GC17329 MLCK inhibitor peptide 18 A selective, cell-permeable inhibitor of MLCK
- GC14326 Calmidazolium chloride An inhibitor of calmodulin
- GC11362 K 252a A non-selective PKC inhibitor
- GC12501 KN-93 hydrochloride A selective inhibitor of Ca2+/calmodulin-dependent kinase type II
- GC13793 NH125 An antibacterial imidazole
- GC10629 KN-93 Selective inhibitor of Ca2+/calmodulin-dependent kinase type II
- GC16981 KN-92 phosphate KN-92 phosphate 是 KN-93 的无活性衍生物,没有 CaM 激酶抑制活性。 KN-92 磷酸盐旨在用作旨在阐明 KN-93 拮抗剂活性的研究中的对照化合物。 KN-93 是一种细胞渗透性、可逆性和竞争性 CaMKII 抑制剂。
- GC15988 KN-92 hydrochloride An inactive control compound for a CaMKII inhibitor
- GC14132 KN-92 An inactive control compound for a CaMKII inhibitor
- GC14202 KN-62 Inhibitor of Ca2+/calmodulin-dependent kinase type II