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Regelidine Sale

(Synonyms: 黑蔓定碱) 目录号 : GC39101

Regelidine 是一种从雷公藤茎中分离得到的天然产物。

Regelidine Chemical Structure

Cas No.:114542-54-0

规格 价格 库存 购买数量
5mg
¥3,627.00
现货
10mg
¥6,174.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

Quality Control & SDS

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产品描述

Regelidine is a natural product isolated from the stems of Tripterygium regelii[1].

[1]. Fan, D., et al. Dihydro-β-agarofuran sesquiterpene polyesters isolated from the stems of Tripterygium regelii. Fitoterapia, 2016;112, 1-8.

Chemical Properties

Cas No. 114542-54-0 SDF
别名 黑蔓定碱
Canonical SMILES C[C@@]12[C@@]3([C@@](O)(CC[C@@H]2OC(C4=CC=CC=C4)=O)C)[C@@]([H])([C@@](C(C)(C)O3)([H])C[C@@H]1OC(C5=CC=CC=C5)=O)OC(C6=CN=CC=C6)=O
分子式 C35H37NO8 分子量 599.67
溶解度 Soluble in DMSO 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

制备储备液
1 mg 5 mg 10 mg
1 mM 1.6676 mL 8.3379 mL 16.6758 mL
5 mM 0.3335 mL 1.6676 mL 3.3352 mL
10 mM 0.1668 mL 0.8338 mL 1.6676 mL
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Research Update

Screening of major hepatotoxic components of Tripterygium wilfordii based on hepatotoxic injury patterns

BMC Complement Med Ther 2023 Jan 10;23(1):9.PMID:36627617DOI:10.1186/s12906-023-03836-w.

Background: Tripterygium wilfordii Hook. F. (TwHF), a traditional Chinese medicine, is widely used in the treatment of rheumatoid arthritis. Due to multiorgan toxicity, particularly hepatotoxicity, the application of TwHF is restricted. To clarify the hepatotoxic substances, zebrafish, hepatocytes and macrophages were used for screening based on hepatotoxic injury patterns. This study provides a basis for further elucidation of the hepatotoxic mechanism of TwHF. Methods: First, 12 compounds were selected according to the chemical categories of TwHF. The fluorescence area and fluorescence intensity of zebrafish livers were observed and calculated. The viability of two hepatocyte lines was detected by CCK8 assay. TNF-α and IL-1β mRNA expression in bone marrow-derived macrophages was used to evaluate macrophage activation, a factor of potential indirect hepatotoxicity. Finally, the hepatotoxic characteristics of 4 representative components were verified in mice in vivo. Results: Parthenolide, triptolide, triptonide, triptobenzene H, celastrol, demethylzeylasteral, wilforlide A, triptotriterpenic acid A and Regelidine significantly reduced the fluorescence area and fluorescence intensity of zebrafish livers. The viability of L-02 or AML-12 cells was significantly inhibited by parthenolide, triptolide, triptonide, celastrol, demethylzeylasteral, and triptotriterpenic acid A. Parthenolide, triptolide, triptonide, celastrol, demethylzeylasteral and triptobenzene H significantly increased TNF-α and IL-1β mRNA levels in macrophages, while triptophenolide, hypodiolide and wilforine significantly reduced TNF-α and IL-1β mRNA levels. Triptotriterpenic acid A, celastrol and triptobenzene H at a dose of 10 mg/kg significantly increased the levels of mouse serum alanine aminotransferase and aspartate aminotransferase and aggravated liver inflammation. Conclusions: Parthenolide, triptolide, triptonide, celastrol, demethylzeylasteral, triptotriterpenic acid A and triptobenzene H might be the main hepatotoxic components of TwFH. Among them, only triptotriterpenic acid A presents direct hepatotoxicity. Triptobenzene H exerts indirect liver damage by activating macrophages. Parthenolide, triptolide, triptonide, celastrol, and demethylzeylasteral can directly and indirectly cause liver injury.