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RB394 Sale

目录号 : GC15909

A dual modulator of sEH and PPARγ

RB394 Chemical Structure

Cas No.:1830320-32-5

规格 价格 库存 购买数量
1mg
¥444.00
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5mg
¥1,951.00
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10mg
¥3,426.00
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25mg
¥7,519.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

RB394 is an orally bioavailable and dual modulator of soluble epoxide hydrolase (sEH) and PPARγ [1].

Soluble epoxide hydrolase (sEH) is a bifunctional enzyme involved in the in vivo metabolism of endogenous lipid epoxides. The sEH is abundantly expressed in adipose tissue. sEH is an enzyme of the arachidonic acid cascade, promoting the hydrolysis of cytochrome P450 derived epoxyeicosatrienoic acids (EETs). Endothelial cell-derived EETs activate calcium-activated potassium channels on smooth muscle cells, leading to hyperpolarization and vascular relaxation. PPARγ, a member of the PPAR nuclear receptor family, plays an important role in adipogenesis, regulation of lipid metabolism and glucose homeostasis, and anti-inflammatory processes [1].

RB394 inhibited the activity of sEH with an IC50 of 0.33 μM and activated PPARγ with an EC50 of 0.3 μM. RB394 was inactive at PPARδ and showed 29% activation of PPARαat 10 μM. In mice, treatment with 30 mg/kg RB394 in drinking water for two weeks resulted in a final plasma concentration of ~3 μM. RB394 upregulated the PPARγ target genes, as well as PPARα and PPARδ in mouse livers [1].

References:
[1] Blocher R, Lamers C, Wittmann S K, et al.  N-Benzylbenzamides: a novel merged scaffold for orally available dual soluble epoxide hydrolase/peroxisome proliferator-activated receptor γ modulators[J]. Journal of medicinal chemistry, 2015, 59(1): 61-81.

Chemical Properties

Cas No. 1830320-32-5 SDF
化学名 α-ethyl-4-[[[[4-methoxy-2-(trifluoromethyl)phenyl]methyl]amino]carbonyl]-benzenepropanoic acid
Canonical SMILES COC1=CC(C(F)(F)F)=C(CNC(C2=CC=C(CC(C(O)=O)CC)C=C2)=O)C=C1
分子式 C21H22F3NO4 分子量 409.4
溶解度 ≤5mg/ml in ethanol;33mg/ml in DMSO;25mg/ml in dimethyl formamide 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.4426 mL 12.213 mL 24.426 mL
5 mM 0.4885 mL 2.4426 mL 4.8852 mL
10 mM 0.2443 mL 1.2213 mL 2.4426 mL
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