Home>>Quisinostat dihydrochloride

Quisinostat dihydrochloride

目录号 GC19936

规格 价格 库存 购买数量
10mM * 1mL in DMSO
¥1,155.00
现货
2mg
¥630.00
现货
5mg
¥1,050.00
现货
10mg
¥1,680.00
现货
50mg
¥5,040.00
现货
100mg
¥8,400.00
现货

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Sample solution is provided at 25 µL, 10mM.

实验参考方法

JNJ-26481585 inhibits HDAC isozymes in vitro[1].
JNJ-26481585 (30-1000 nM; 24 hours) is a potent pan-HDAC inhibitor in tumor cells[1].
JNJ-26481585 has broad spectrum antiproliferative activity against solid and hematologic cancer cell lines and induces apoptosis[1].

JNJ-26481585 (40 mg/kg; p.o.; once daily, for 3 days) as a potent HDAC1 inhibitor p21waf1,cip1 ZsGreen tumors in vivo[1].
JNJ-26481585 induces continuous H3 acetylation in tumor tissue in vivo[1].
JNJ-26481585 (10 mg/kg; once daily; i.p.; for 14 days) strongly inhibits the growth of large pre-established HCT116 colon xenografts[1].

产品描述

Quisinostat dihydrochloride (JNJ-26481585 dihydrochloride) is an orally available, potent pan-HDAC inhibitor with IC50s of 0.11 nM, 0.33 nM, 0.64 nM, 0.46 nM, and 0.37 nM for HDAC1, HDAC2, HDAC4, HDAC10 and HDAC11, respectively. Quisinostat dihydrochloride has a broad spectrum antitumoral activity[1].

Chemical Properties

Cas No. 875320-31-3 SDF N/A
别名 JNJ-26481585 dihydrochloride
化学名 N/A
Canonical SMILES N/A
分子式 C21H28CI12N6O2 分子量 467.39
溶解度 N/A 储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
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第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系GLPBIO为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
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