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Quinacrine (hydrochloride hydrate) Sale

(Synonyms: Atebrine,Mepacrine) 目录号 : GC12439

An acridine compound with diverse biological activities and cell labeling properties

Quinacrine (hydrochloride hydrate) Chemical Structure

Cas No.:6151-30-0

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Sample solution is provided at 25 µL, 10mM.

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产品描述

IC50: 3.3 μM

Ki = 6.7 μM

Quinacrine, also commonly known as atebrine, is a compound which is commonly used as an anti-protozoal agent. It inhibits voltage-dependent sodium channels with an IC50 value of 3.3 μM and suppresses aldehyde oxidase with an IC50 value of 3.3 μM. Quinacrine prevents misfolding of prion protein with an EC50 value of 0.3 μM. As an effective riboflavin antagonist, quinacrine associates with the riboflavin-binding protein with a Ki value of 6.7 μM. Voltage-dependent sodium channels play a vital role in action potential initiation and propagation in excitable cells, including muscle, nerve, and neuroendocrine cell types.

In vitro: Quinacrine, in a dose-dependent manner, effectively reversed the resistance in the multi-drug resistance (MDR) K562 cells. Quinacrine displayed strong toxicity to the MDR K562 cells at a concentration of 10.0 μM. Compared to the control, quinacrine significantly increased the activity of caspase-9 and -3 activities in the MDR K562 and K562 cells in a dose-dependent fashion [1].

In vivo: Female BALB/c nude mice, bearing MDR K562 cell xenografts, were injected with quinacrine at a dose of 10 mg/kg via tail vein for 13 days. Compared to the control group, quinacrine inhibited the tumor growth obviously in the treated groups. Furthermore, quinacrine enhanced the anti-tumor effects of vincristine [1].

Reference:
[1].Liang, G. , Lu, W., Wu, J., Zhao, J., Hong, H., & Long, C. et al. Enhanced therapeutic effects on the multi-drug resistant human leukemia cells in vitro and xenograft in mice using the stealthy liposomal vincristine plus quinacrine. Fundamental & Clinical Pharmacology.2008; 22(4): 429-437.

Chemical Properties

Cas No. 6151-30-0 SDF
别名 Atebrine,Mepacrine
化学名 N4-(6-chloro-2-methoxyacridin-9-yl)-N1,N1-diethylpentane-1,4-diamine, dihydrochloride hydrate
Canonical SMILES ClC1=CC=C2C(NC(C)CCCN(CC)CC)=C3C(C=CC(OC)=C3)=NC2=C1.Cl.Cl.O
分子式 C23H30ClN3O • 2HCl [XH2O] 分子量 472.9
溶解度 ≥ 18.65mg/mL in Water 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.1146 mL 10.5731 mL 21.1461 mL
5 mM 0.4229 mL 2.1146 mL 4.2292 mL
10 mM 0.2115 mL 1.0573 mL 2.1146 mL
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