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Pyrantel tartrate Sale

(Synonyms: 酒石酸噻嘧啶) 目录号 : GC32156

Pyrantel酒石酸盐是一种驱线虫噻吩;烟碱受体激动剂。

Pyrantel tartrate Chemical Structure

Cas No.:33401-94-4

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥446.00
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100mg
¥313.00
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500mg
¥803.00
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产品描述

Pyrantel tartrate is an antinematodal thiophene; nicotinic receptor agonist and can elicit spastic muscle paralysis in parasitic worms due to prolonged activation of the excitatory nicotinic acetylcholine (nACh) receptors on body wall muscle.

[1]. Aceves J, et al. The mechanism of the paralysing action of tetramisole on Ascaris somatic muscle. Br J Pharmacol. 1970 May;38(3):602-7. [2]. Aubry ML, et al. Aspects of the pharmacology of a new anthelmintic: pyrantel. Br J Pharmacol. 1970 Feb;38(2):332-44.

Chemical Properties

Cas No. 33401-94-4 SDF
别名 酒石酸噻嘧啶
Canonical SMILES CN1CCCN=C1/C=C/C2=CC=CS2.O=C(O)[C@H](O)[C@@H](O)C(O)=O
分子式 C15H20N2O6S 分子量 356.39
溶解度 DMSO : ≥ 34 mg/mL (95.40 mM) 储存条件 Store at -20°C
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1 mg 5 mg 10 mg
1 mM 2.8059 mL 14.0296 mL 28.0591 mL
5 mM 0.5612 mL 2.8059 mL 5.6118 mL
10 mM 0.2806 mL 1.403 mL 2.8059 mL
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Research Update

Pyrantel pamoate resistance in horses receiving daily administration of Pyrantel tartrate

J Am Vet Med Assoc 2006 Jan 1;228(1):101-3.PMID:16426178DOI:10.2460/javma.228.1.101.

Case descriptions: 16 horses treated daily with Pyrantel tartrate (2.64 mg/kg [1.2 mg/lb], PO) as part of a prophylactic anthelmintic program. Clinical findings: Fecal worm egg counts (FWECs) were obtained on all 16 horses. Mean FWEC was 478 eggs/g (epg; range, 0 to 4,075 epg). Three of the 16 horses were responsible for 85% of the total fecal egg output for the herd on the day of sampling. Six horses had FWECs < 200 epg. Three horses that had arrived within 4 months of the sampling date had FWECs < 100 epg. Treatment and outcome: An FWEC reduction test was initiated the day after FWECs were obtained; all horses with FWECs > 100 epg (9 horses) were treated with pyrantel pamoate (6.6 mg/kg [3 mg/lb], PO), and 14 days later, the FWEC was repeated. During the 14-day period, all horses received Pyrantel tartrate (2.64 mg/kg, PO) daily. Fecal worm egg count reduction was calculated for each horse. Mean FWEC reduction for the group was 28.5% (range, increase of 21% in FWECs 14 days after treatment to a decrease of 100% in FWEC 14 days after treatment). Clinical relevance: Farms should be monitored for cyathostomes resistant to pyrantel pamoate prior to use of Pyrantel tartrate. Fecal worm egg counts should be monitored routinely in horses before and after treatment to ensure efficacy of cyathostome control measures.

Effects of daily Pyrantel tartrate on strongylid population dynamics and performance parameters of young horses repeatedly infected with cyathostomins and Strongylus vulgaris

Vet Parasitol 2014 Aug 29;204(3-4):229-37.PMID:24929448DOI:10.1016/j.vetpar.2014.05.034.

Strongylid infections are ubiquitous in grazing horse populations. Infections with cyathostomin (small strongyle) and strongylin (large strongyle) nematodes have long been associated with clinical disease in horses, but little is known about their subclinical impact. A masked, randomized, controlled study was conducted to evaluate the effects of daily administration of Pyrantel tartrate on body condition scores, weight gain, fecal egg counts, and total worm counts of young horses repeatedly inoculated with strongylid larvae. Twenty eight immature horses were treated with larvicidal anthelmintic regimens and randomly allocated to two groups. Group 1 horses were given a pelleted placebo product once daily, and those in Group 2 received Pyrantel tartrate once daily at ∿2.64 mg/kg body weight. On five days during each week, ∿5000 infective cyathostomin larvae were administered to each horse. In addition, horses received ∿25 infective Strongylus vulgaris larvae once weekly. Horses were maintained on pasture for 154 days and had ad libitum access to grass hay throughout. At approximate, 14-day intervals, body weights were measured, body condition scores were assigned, fecal samples were collected for egg counts, and blood samples were collected for measurement of S. vulgaris antibodies and various physiologic parameters. After 22 weeks at pasture and 14-17 days in confinement, horses were euthanatized and necropsied. Nematodes were recovered and counted from aliquots of organ contents, representative samples of large intestinal mucosa, and the root of the cranial mesenteric artery. Daily treatment with Pyrantel tartrate at the recommended dosage significantly reduced numbers of adult cyathostomins in the gut lumen and early third-stage larvae in the cecal mucosa, increased the proportions of fourth-stage larvae in the gut contents, and was accompanied by significant improvements in body condition scores. Fecal egg counts of horses receiving daily Pyrantel tartrate were significantly reduced, with percentages of efficacy ranging from 84.4% to 98.9%, but egg counts of both groups increased significantly over the course of the study. Treatment also significantly reduced the numbers of S. vulgaris larvae in the cranial mesenteric artery by 99.2%. Serum antibodies to S. vulgaris apparently persisted from pre-enrollment infections, but ELISA values gradually declined over the course of the study. This study has provided useful insights into the effects of daily Pyrantel tartrate on the dynamics of cyathostomin infection, and into some subclinical effects of strongylid parasitism in horses.

Efficacy of Pyrantel tartrate against experimental infections with Haemonchus contortus, Teladorsagia circumcincta and Trichostrongylus colubriformis in goats

Vet Parasitol 1995 Aug;59(1):69-73.PMID:7571339DOI:10.1016/0304-4017(94)00737-w.

The efficacy of Pyrantel tartrate was evaluated in goats against induced infections with Haemonchus contortus, Teladorsagia circumcincta and Trichostrongylus colubriformis. All the strains were of sheep origin and tested for susceptibility to Pyrantel tartrate in sheep at the standard dose rate (20 mg kg-1) prior to the infection of goats. Fifteen French Alpine female goats were inoculated with the three nematode species. On Day 25 post-infection, goats were randomized into an untreated control group and two pyrantel treatment groups (20 mg kg-1 bodyweight once, and 40 mg kg-1 bodyweight as two doses 24 h apart). The goats were killed and processed for worm recovery 10 days after treatment. The two dose rates achieved high and similar levels of efficacy (> 96%) against Haemonchus contortus and Teladorsagia circumcincta. Against Trichostrongylus colubriformis, however, Pyrantel tartrate was less effective at both dose rates as worm reductions ranged from 55 to 62%.

Activity of selected antioxidative enzymes in rats exposed to dimethoate and Pyrantel tartrate

Pol J Vet Sci 2012;15(2):239-45.PMID:22844700DOI:10.2478/v10181-011-0140-6.

This study presents the results of research concerning the effect of single and combined application of Pyrantel tartrate and dimethoate on selected antioxidative enzymes: catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx), in rat erythrocytes. Pyrantel tartrate was applied twice, at a dose of 85 mg/kg bw at a two week interval, i.e. on day 14 and 28 of the experiment, orally, in a water solution with a stomach tube. Dimethoate was administered with drinking water for 28 days at a dose of 25 mg/kg bw/day. It was found that Pyrantel tartrate caused only small changes in the activity of the antioxidative enzymes under analysis. Subchronic exposure of rats to dimethoate caused a significant increase in the activity of CAT, SOD and GPx in erythrocytes, indicating the existence of strong oxidative stress. In combined intoxication, no significant effects of administering Pyrantel tartrate on the activity of CAT, SOD and GPx was found in animals poisoned with dimethoate. The profile of changes was similar to that observed in rats exposed only to the organophosphorus insecticide. This may indicate a lack of interaction between the compounds used in the experiment.

Relative efficacies of Pyrantel tartrate and pyrantel citrate against Oesophagostomum sp in swine

Am J Vet Res 1981 May;42(5):871-2.PMID:7258809doi

The relative efficacies of Pyrantel tartrate and of pyrantel citrate against Oesophagostomum sp in swine were evaluated in a controlled-critical study and the efficacy of pyrantel citrate in a field trial. In the controlled-critical study, pigs naturally infected with Oesophagostomum dentatum were either not treated or were treated with pyrantel citrate or Pyrantel tartrate at a dosage of 510 mg of free pyrantel base/kg of feed. Six days later, the pigs were necropsied, adult O dentatum was recovered and counted, and fecal samples were examined for helminth eggs. The efficacies of pyrantel citrate and Pyrantel tartrate were each 100% based on fecal egg counts and numbers of adults at necropsy. The field trial was conducted in a similar manner except that pyrantel citrate only was tested against a control group on the basis of fecal egg counts made both at the beginning and at the termination of the trial. In this study pyrantel citrate was found to reduce Oesophagostomum sp egg counts by 89.4%.