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PX 12 Sale

(Synonyms: 2-(仲丁基二硫基)-1H-咪唑,IV-2) 目录号 : GC15594

An irreversible inhibitor of thioredoxin-1

PX 12 Chemical Structure

Cas No.:141400-58-0

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥462.00
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5mg
¥420.00
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10mg
¥595.00
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50mg
¥2,100.00
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100mg
¥3,500.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

PX 12 is an inhibitor of thioredoxin-1 [1].

Thioredoxin-1 (Trx-1) is a small redox protein with a conserved catalytic site and plays an important role in cells that includes the regulation of trans-activating activity and the DNA binding of redox-sensitive transcription factors [1].

In HT-29 human colon carcinoma cells and MCF-7 human breast cancer, PX 12 prevented the hypoxia-induced increase in HIF-1 protein. Also, PX 12 decreased inducible nitric oxide synthase, HIF-1-trans-activating activity and VEGF formation [2].

In immunodeficient mice bearing HT-29 human colon xenografts, PX 12 decreased the average tumor blood vessel permeability by 63% within 2 hours and returned to pretreatment values after 48 hours. PX 12 reduced tumor-derived VEGF and tumor after 24 hours. Also, Trx-1 showed a rapid decrease within 2 hours and maintained for 24 hours [1]. In mice bearing MCF-7 tumor xenografts, PX 12 reduced HIF-1ɑ and VEGF protein levels [2]. In cancer patients, PX-12 treatment significantly reduced the levels of Trx-1 and VEGF in plasma [3].

References:
[1].  Jordan BF, Runquist M, Raghunand N, et al. The thioredoxin-1 inhibitor 1-methylpropyl 2-imidazolyl disulfide (PX-12) decreases vascular permeability in tumor xenografts monitored by dynamic contrast enhanced magnetic resonance imaging. Clin Cancer Res, 2005, 11(2 Pt 1): 529-536.
[2].  Welsh SJ, Williams RR, Birmingham A, et al. The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1alpha and vascular endothelial growth factor formation. Mol Cancer Ther, 2003, 2(3): 235-243.
[3].  Baker AF, Dragovich T, Tate WR, et al. The antitumor thioredoxin-1 inhibitor PX-12 (1-methylpropyl 2-imidazolyl disulfide) decreases thioredoxin-1 and VEGF levels in cancer patient plasma. J Lab Clin Med, 2006, 147(2): 83-90.

Chemical Properties

Cas No. 141400-58-0 SDF
别名 2-(仲丁基二硫基)-1H-咪唑,IV-2
化学名 2-(butan-2-yldisulfanyl)-1H-imidazole
Canonical SMILES CCC(C)SSC1=NC=CN1
分子式 C7H12N2S2 分子量 188.31
溶解度 ≥ 8.75mg/mL in DMSO, ≥ 99 mg/mL in EtOH 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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1 mg 5 mg 10 mg
1 mM 5.3104 mL 26.552 mL 53.1039 mL
5 mM 1.0621 mL 5.3104 mL 10.6208 mL
10 mM 0.531 mL 2.6552 mL 5.3104 mL
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