Home>>PtdIns-(3,4,5)-P3 (1,2-dipalmitoyl)-d62 (sodium salt)

PtdIns-(3,4,5)-P3 (1,2-dipalmitoyl)-d62 (sodium salt) Sale

(Synonyms: DPPI3,4,5P3d62, Phosphatidylinositol3,4,5trisphosphate C16d62) 目录号 : GC48010

A neuropeptide with diverse biological activities

PtdIns-(3,4,5)-P3 (1,2-dipalmitoyl)-d62 (sodium salt) Chemical Structure

规格 价格 库存 购买数量
25 μg
¥1,284.00
现货
50 μg
¥2,449.00
现货
100 μg
¥4,625.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

PtdIns-(3,4,5)-P3 (1,2-dipalmitoyl)-d62 (sodium salt) contains 62 deuterium atoms at the 2, 2', 3, 3', 4, 4', 5, 5', 6, 6', 7, 7', 8, 8', 9, 9', 10, 10', 11, 11', 12, 12', 13, 13', 14, 14', 15, 15', 16, 16, and 16 positions of each fatty acyl chain. It is intended for use as an internal standard for the quantification of PtdIns-(3,4,5)-P3 (1,2-dipalmitoyl) (sodium salt) by GC- or LC-mass spectrometry (MS). The phosphatidylinositol phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals.1,2 PtdIns-(3,4,5)-P3 can serve as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains. Centuarin α and the Akt-family of GTPase activating proteins are examples of PtdIns-(3,4,5)-P3-binding proteins.3,4 Protein-binding to PtdIns-(3,4,5)-P3 is important for cytoskeletal rearrangements and membrane trafficking. PtdIns-(3,4,5)-P3 is resistant to cleavage by PI-specific phospholipase C (PLC). Thus, it is likely to function in signal transduction as a modulator in its own right, rather than as a source of inositol tetraphosphates. For further reading on inositol phospholipids, see references 5 and 6.

1.Lapetina, E.G., Billah, M.M., and Cuatrecasas, P.The phosphatidylinositol cycle and the regulation of arachidonic acid productionNature292367-369(1981) 2.Majerus, P.W.Inositol phosphate biochemistryAnnu. Rev. Biochem.61225-250(1992) 3.Tanaka, K., Imajoh-Ohmi, S., Sawada, T., et al.A target of phosphatidylinositol 3,4,5-trisphosphate with a zinc finger motif similar to that of the ADP-ribosylation-factor GTPase-activating protein and two pleckstrin homology domainsEuropean Journal of Biochemistry245512-519(1997) 4.Yang, X., Rudolf, M., Carew, M.A., et al.Inositol 1,3,4-trisphosphate acts in vivo as a specific regulator of cellular signaling by inositol 3,4,5,6-tetrakisphosphateThe Journal of Biological Chemisty27418973-18980(1999) 5.Pike, L.J., and Casey, L.Localization and turnover of phosphatidylinositol 4,5-bisphosphate in caveolin-enriched membrane domainsThe Journal of Biological Chemisty27126453-26456(1996) 6.Berridge, M.J.Inositol trisphosphate and calcium signallingNature361(6410)315-325(1993)

Chemical Properties

Cas No. N/A SDF
别名 DPPI3,4,5P3d62, Phosphatidylinositol3,4,5trisphosphate C16d62
Canonical SMILES O[C@@H]1[C@@H](OP([O-])(O)=O)[C@H](OP([O-])(O)=O)[C@@H](OP([O-])(O)=O)[C@@H](O)[C@H]1OP([O-])(OCC(COC(C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H
分子式 C41H16D62O22P4.4Na 分子量 1201.3
溶解度 Water: 10 mg/ml 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 0.8324 mL 4.1622 mL 8.3243 mL
5 mM 0.1665 mL 0.8324 mL 1.6649 mL
10 mM 0.0832 mL 0.4162 mL 0.8324 mL
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