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Psoralen Sale

(Synonyms: 补骨脂素; Ficusin) 目录号 : GN10451

A photoactive probe to study DNA

Psoralen Chemical Structure

Cas No.:66-97-7

规格 价格 库存 购买数量
20mg
¥704.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Psoralen (Furocoumarin) is an active ingredient from Fructus Psoraleae; has anticancer activity.IC50 value:Target:in vitro: Psoralen dosages of 1-10 μM exhibited low cytotoxicity toward chondrocytes. However, a dosage of 100 μM suppressed the proliferation of chondrocytes. Different concentrations of psoralen treatments on chondrocytes revealed that GAG and Type II collagen synthesis increased, especially at 100 μM, by 0.39-fold and 0.48-fold, respectively, on day 3, and by 0.51-fold and 0.56-fold, respectively, on day 9 [1]. in vivo: Tumor volume inhibition rates were 43.75% and 40.18%, respectively, in the psoralen and isopsoralen low-dose groups, and tumor weight inhibition rates were 38.83% and 37.77%. Tumor volume inhibition rates were 67.86% and 66.96%, respectively, in the psoralen and isopsoralen high-dose groups, and tumor weight inhibition rates were 49.47% and 47.87% [2]. psoralen can inhibit metastasis of breast cancer to bone in vivo. Histological, molecular biological, and imaging analyses revealed that psoralen inhibits bone metastases in mice [3].

References:
[1]. Xu K, et al. Psoralen activates cartilaginous cellular functions of rat chondrocytes in vitro. Pharm Biol. 2014 Dec 4:1-6.
[2]. Lu H, et al. Isolation and purification of psoralen and isopsoralen and their efficacy and safety in the treatment of osteosarcoma in nude rats. Afr Health Sci. 2014 Sep;14(3):641-7.
[3]. Wu C, et al. Psoralen inhibits bone metastasis of breast cancer in mice. Fitoterapia. 2013 Dec;91:205-10.

Chemical Properties

Cas No. 66-97-7 SDF
别名 补骨脂素; Ficusin
化学名 furo[3,2-g]chromen-7-one
Canonical SMILES C1=CC(=O)OC2=CC3=C(C=CO3)C=C21
分子式 C11H6O3 分子量 186.17
溶解度 ≥ 6.2mg/mL in DMSO with ultrasonic and warming 储存条件 Store at 4°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mM 5.3714 mL 26.8572 mL 53.7143 mL
5 mM 1.0743 mL 5.3714 mL 10.7429 mL
10 mM 0.5371 mL 2.6857 mL 5.3714 mL
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