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Prostaglandin J2-d4 Sale

(Synonyms: PGJ2-d4) 目录号 : GC48002

A neuropeptide with diverse biological activities

Prostaglandin J2-d4 Chemical Structure

规格 价格 库存
25 μg
¥1,371.00
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50 μg
¥2,604.00
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100 μg
¥4,935.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Prostaglandin J2-d4 is intended for use as an internal standard for the quantification of prostaglandin J2 by GC- or LC-MS. Prostaglandin J2 (PGJ2) is formed from PGD2 by the elimination of the C-9 hydroxyl group, a process which is accelerated by the presence of albumin.1 PGJ2 inhibits platelet aggregation with an IC50 of about 5-10 nM.2,3 PGJ2 has antimitotic and antiproliferative effects on a variety of cultured normal cells and tumor cell lines.4 However, this activity has been attributed to further metabolites of PGJ2 and not the parent compound itself.

1.Fitzpatrick, F.A., and Wynalda, M.A.Albumin-catalyzed metabolism of prostaglandin D2. Identification of products formed in vitroJ. Biol. Chem.258(19)11713-11718(1983) 2.Bundy, G.L., Morton, D.R., Peterson, D.C., et al.Synthesis and platelet aggregation inhibiting activity of prostaglandin D analoguesJ. Med. Chem.26(6)790-799(1983) 3.Mahmud, I., Smith, D.L., Whyte, M.A., et al.On the identification and biological properties of prostaglandin J2Prostaglandins Leukot. Med.16(2)131-146(1984) 4.Fukushima, M.Prostaglandin J2 - anti-tumor and anti-viral activities and the mechanisms involvedEicosanoids3(4)189-199(1990)

Chemical Properties

Cas No. N/A SDF
别名 PGJ2-d4
Canonical SMILES CCCCC[C@H](O)/C=C/[C@H]([C@@H](C/C=C\C([2H])([2H])C([2H])([2H])CC(O)=O)C=C1)C1=O
分子式 C20H26D4O4 分子量 338.5
溶解度 DMF: 50 mg/ml,DMSO: 50 mg/ml,Ethanol: 50 mg/ml,PBS (pH 7.2): 1 mg/ml 储存条件 Store at -80°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.9542 mL 14.771 mL 29.5421 mL
5 mM 0.5908 mL 2.9542 mL 5.9084 mL
10 mM 0.2954 mL 1.4771 mL 2.9542 mL
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