Home>>Signaling Pathways>> Cancer Biology Peptides>> Cancer Biology>>Pro-Adrenomedullin (153-185), human
Pro-Adrenomedullin (153-185), human 目录号 GP10072

Vasodilator

规格 价格 库存
1mg
¥1,155.00
询价
5mg
¥3,192.00
询价
10mg
¥5,586.00
询价
25mg
¥7,865.00
询价

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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. N/A SDF
别名 H2N-Ser-Leu-Pro-Glu-Ala-Gly-Pro-Gly-Arg-Thr-Leu-Val-Ser-Ser-Lys-Pro-Gln-Ala-His-Gly-Ala-Pro-Ala-Pro-Pro-Ser-Gly-Ser-Ala-Pro-His-Phe-Leu-OH
化学名 N/A
Canonical SMILES N/A
分子式 C143H224N42O43 分子量 3219.6
溶解度 N/A 储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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产品描述

Pro-Adrenomedullin(153-185),human, (C143H224N42O43), a peptide with the sequence H2N-SLPEAGPGRTLVSSKPQAHGAPAPPSGSAPHFL-OH, MW= 3219.6. Adrenomedullin (AM) is a ubiquitously expressed peptide initially isolated from phaechromyctoma in 19931. AM was initially identified as a vasodilator, some have cited this as the most potent endogenous vasodilatory peptide found in the body 2. Differences in opinion regarding the ability of AM to relax vascular tone arises from the differences in the model system used 3. Other effects of AM include increasing the tolerance of cells to oxidative stress and hypoxic injury and angiogenesis. AM is seen as a positive influence in diseases such as hypertension, myocardial infarction, chronic obstructive pulmonary disease and other cardiovascular diseases, whereas it can be seen as a negative factor in potentiating the potential of cancerous cells to extend their blood supply and cause cell proliferation.

References:
1.Kitamura K, Kato J, Kawamoto M, Tanaka M, Chino N, Kangawa K, et al. The intermediate form of glycine-extended adrenomedullin is the major circulating molecular form in human plasma. Biochem Biophys Res Commun 1998;244:551-555
2. Cockcroft et al., Br J Clin Pharmacol. 1997 Jul;44(1):57-60.
3. Hamid SA, Baxter GF, Pharmacol Ther. Feb;105(2):95-112.2005.