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Potassium Canrenoate Sale

(Synonyms: 坎利酸钾) 目录号 : GC12525

Aldosterone antagonist

Potassium Canrenoate Chemical Structure

Cas No.:2181-04-6

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1g
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5g
¥1,092.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Potassium canrenoate is a competitive antagonist of aldosterone receptor [1].

Aldosterone is a steroid hormone and plays an important role in the regulation of blood pressure by increasing reabsorption of ions and water in the kidney.

In cultured rat and human cells, potassium canrenoate produced genotoxic effects in a doce-dependant way [2].

In male Wistar rats injected with isoprenaline (400 mg/kg), heart and left ventricular weights increased significantly. While potassium canrenoate (20 mg/kg/day) relieved this increase. Potassium canrenoate significantly reduced the fibrosis induced by isoprenaline [1]. In 30 essential hypertensives, canrenoate potassium reduced intraerythrocyte Na+ content and increased Na-K pump [3]. In 15 patients with idiopathic primary aldosteronism, potassium canrenoate normalized the aldosterone/plasma renin activity (PRA) ratio [4].

References:
[1].  Bos R, Mougenot N, Médiani O, et al. Potassium canrenoate, an aldosterone receptor antagonist, reduces isoprenaline-induced cardiac fibrosis in the rat. J Pharmacol Exp Ther, 2004, 309(3): 1160-1166.
[2].  Martelli A, Mattioli F, Carrozzino R, et al. Genotoxicity testing of potassium canrenoate in cultured rat and human cells. Mutagenesis, 1999, 14(5): 463-472.
[3].  Niutta E, Cusi D, Colombo R, et al. Antihypertensive effect of captopril, canrenoate potassium, and atenolol. Relations with red blood cell sodium transport and renin. Am J Hypertens, 1988, 1(4 Pt 1): 364-371.
[4].  Armanini D, Scaroni C, Mattarello MJ, et al. Idiopathic primary hyperaldosteronism: normalization of plasma aldosterone after one month withdrawal of long-term therapy with aldosterone-receptor antagonist potassium canrenoate. J Endocrinol Invest, 2005, 28(3): 236-240.

Chemical Properties

Cas No. 2181-04-6 SDF
别名 坎利酸钾
化学名 potassium;3-[(8R,9S,10R,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl]propanoate
Canonical SMILES CC12CCC(=O)C=C1C=CC3C2CCC4(C3CCC4(CCC(=O)[O-])O)C.[K+]
分子式 C22H29KO4 分子量 396.56
溶解度 ≥ 117.4mg/mL in Water 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.5217 mL 12.6084 mL 25.2169 mL
5 mM 0.5043 mL 2.5217 mL 5.0434 mL
10 mM 0.2522 mL 1.2608 mL 2.5217 mL
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