Home>>Signaling Pathways>> PI3K>> PI3K/Akt/mTOR Signaling>>PI4KIIIbeta-IN-9
PI4KIIIbeta-IN-9 目录号 GC32847

规格 价格 库存 购买数量
10mM*1mLinDMSO
¥5,310.00
现货
1mg
¥990.00
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5mg
¥3,150.00
现货
10mg
¥5,310.00
现货
25mg
¥11,700.00
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50mg
¥18,900.00
现货

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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 1429624-84-9 SDF Download SDF
别名 N/A
化学名 N/A
Canonical SMILES CC(N=C1NC(C2CCCC2)=O)=C(S1)C3=CC=C(C(S(=O)(NC4=CC=C(O)C=C4)=O)=C3)OC
分子式 C23H25N3O5S2 分子量 487.59
溶解度 Soluble in DMSO 储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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产品描述

PI4KIIIbeta-IN-9 is a potent PI4KIIIβ inhibitor with an IC50 of 7 nM. PI4KIIIbeta-IN-9 also inhibits PI3Kδ and PI3Kγ with IC50s of 152 nM and 1046 nM, respectively.

PI4KIIIbeta-IN-9 (Compound 9) shows weak inhibition of PI3KC2γ (IC50 ~1 µM), PI3Kα (~2 µM), and PI4KIIIα (~2.6 µM) and <50% inhibition at concentrations up to 20 µM for PI4K2α, PI4K2β, and PI3Kβ. PI4KIIIbeta-IN-9 (Compound 9) forms a crescent shape that conforms to the active site of PI4KIIIβ. This molecule makes extensive contacts with PI4KIIIβ[1].

[1]. Rutaganira FU, et al. Design and Structural Characterization of Potent and Selective Inhibitors of Phosphatidylinositol 4 Kinase IIIβ. J Med Chem. 2016 Mar 10;59(5):1830-9.