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PHCCC Sale

(Synonyms: N-苯基-7-(羟基亚胺基)环丙烯并[B]苯并吡喃-1A-甲酰胺) 目录号 : GC17383

PHCCC 是 I 组 mGluR 拮抗剂,IC50 为 3 μM。 PHCCC 是 mGlu4 受体的选择性正调节剂。抗帕金森效应。

PHCCC Chemical Structure

Cas No.:179068-02-1

规格 价格 库存 购买数量
10mg
¥900.00
现货
50mg
¥3,600.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

PHCCC is a Group I metabotropic glutamate receptor antagonist with EC50 of 6 uM and a positive allosteric modulator of mGluR4. Also as a potent to antagonism for mGluR2 and mGluR8.target: a Group I metabotropic glutamate receptor antagonistEC 50: 6 uMIn vitro: PHCCC potentiates L-AP4-mediated inhibition of striatopallidal synaptic transmission in vitro. In vivo: 1, PHCCC produced antiparkinsonian efficacy in the reserpinized rat model means a significant level of glutamate is available for the activation of the therapeutically relevant mGluR4. 2, The reference for animal administration is 10 mg/kg.(i.p) 3,PHCCC augmentes in vivo genetic and pharmacological models of absence seizures in rats.

References:
[1]. Marino MJ et al. Allosteric modulation of group III metabotropic glutamate receptor 4: a potential approach to Parkinson's disease treatment. Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13668-73.
[2]. Maj M et al. (-)-PHCCC, a positive allosteric modulator of mGluR4: characterization, mechanism of action, and neuroprotection. Neuropharmacology. 2003 Dec;45(7):895-906.
[3]. Szczurowska E et al. Positive allosteric modulator of mGluR4 PHCCC exhibits proconvulsant action in three models of epileptic seizures in immature rats. Physiol Res. 2012;61(6):619-28.
[4]. Domin H et al. Neuroprotective potential of the group III mGlu receptor agonist ACPT-I in animal models of ischemic stroke: In vitro and in vivo studies. Neuropharmacology. 2016 Mar;102:276-94.

Chemical Properties

Cas No. 179068-02-1 SDF
别名 N-苯基-7-(羟基亚胺基)环丙烯并[B]苯并吡喃-1A-甲酰胺
化学名 (1aS,7aS,Z)-7-(hydroxyimino)-N-phenyl-1,1a,7,7a-tetrahydrocyclopropa[b]chromene-1a-carboxamide
Canonical SMILES O=C([C@]1([C@H]/2C1)OC3=CC=CC=C3C2=N/O)NC4=CC=CC=C4
分子式 C17H14N2O3 分子量 294.31
溶解度 Soluble in DMSO 储存条件 Store at RT
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1 mM 3.3978 mL 16.9889 mL 33.9778 mL
5 mM 0.6796 mL 3.3978 mL 6.7956 mL
10 mM 0.3398 mL 1.6989 mL 3.3978 mL
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