Penicillin G Procaine
(Synonyms: 普鲁卡因青霉素G,PGP hydrate) 目录号 : GC39543
Procaine benzylpenicillin (Procaine benzylpenicillin,PGP), also known as Procaine benzylpenicillin, is an antibiotic useful for the treatment of a number of bacterial infections.
Cas No.:6130-64-9
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Procaine benzylpenicillin (Procaine benzylpenicillin,PGP), also known as Procaine benzylpenicillin, is an antibiotic useful for the treatment of a number of bacterial infections.
| Cas No. | 6130-64-9 | SDF | |
| 别名 | 普鲁卡因青霉素G,PGP hydrate | ||
| Canonical SMILES | O=C([C@@H](C(C)(C)S[C@]1([H])[C@@H]2NC(CC3=CC=CC=C3)=O)N1C2=O)O.O=C(OCCN(CC)CC)C4=CC=C(N)C=C4.[H]O[H] | ||
| 分子式 | C29H40N4O7S | 分子量 | 588.72 |
| 溶解度 | DMSO: 250 mg/mL (424.65 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.6986 mL | 8.493 mL | 16.986 mL |
| 5 mM | 0.3397 mL | 1.6986 mL | 3.3972 mL |
| 10 mM | 0.1699 mL | 0.8493 mL | 1.6986 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Pharmacokinetics of Penicillin G Procaine versus penicillin G potassium and procaine hydrochloride in horses
Am J Vet Res 2000 Jul;61(7):811-5.PMID:10895905DOI:10.2460/ajvr.2000.61.811.
Objective: To compare the pharmacokinetics of penicillin G and procaine in racehorses following i.m. administration of Penicillin G Procaine (PGP) with pharmacokinetics following i.m. administration of penicillin G potassium and procaine hydrochloride (PH). Animals: 6 healthy adult mares. Procedure: Horses were treated with PGP (22,000 units of penicillin G/kg of body weight, i.m.) and with penicillin G potassium (22,000 U/kg, i.m.) and PH (1.55 mg/kg, i.m.). A minimum of 3 weeks was allowed to elapse between drug treatments. Plasma and urine penicillin G and procaine concentrations were measured by use of high-pressure liquid chromatography. Results: Median elimination phase half-lives of penicillin G were 24.7 and 12.9 hours, respectively, after administration of PGP and penicillin G potassium. Plasma penicillin G concentration 24 hours after administration of penicillin G potassium and PH was not significantly different from concentration 24 hours after administration of PGP. Median elimination phase half-life of procaine following administration of PGP (15.6 hours) was significantly longer than value obtained after administration of penicillin G potassium and PH (1 hour). Conclusions and clinical relevance: Results suggest that i.m. administration of penicillin G potassium will result in plasma penicillin G concentrations for 24 hours after drug administration comparable to those obtained with administration of PGP Clearance of procaine from plasma following administration of penicillin G potassium and PH was rapid, compared with clearance following administration of PGP.
Penicillin G Procaine: a possible cause of embryonic death in swine
Vet Rec 1980 Feb 2;106(5):97-8.PMID:7361408DOI:10.1136/vr.106.5.97.
A field case involving seven recently inseminated Yorkshire sows injected with penicillin is described. About four hours after injection, the pigs showed shivering, incoordination, vomiting, extreme lassitude, pyrexia (41 degrees C) and to;al inappetence. In each case, a thick, white mucous discharge appeared from the vulva one to three days after injection, with distinct embryos in some cases. Further experiments on pregnant and fattening pigs indicated that untoward reactions to penicillin could arise in swine--in particular, embryonic death.
Depletion of penicillin G residues in heavy sows after intramuscular injection. Part I: tissue residue depletion
J Agric Food Chem 2014 Jul 30;62(30):7577-85.PMID:25025185DOI:10.1021/jf501492v.
Heavy sows (n = 126) were treated with Penicillin G Procaine at a 5× label dose (33 000 IU/kg) for 3 consecutive days by intramuscular (IM) injection using three patterns of drug administration. Treatments differed by injection pattern and injection volume. Sets of sows were slaughtered 5, 10, 15, 20, 25, 32, and 39 days after the last treatment; skeletal muscle, kidney, serum, and urine were collected for penicillin G analysis by LC-MS/MS. Penicillin G at withdrawal day 5 averaged 23.5 ± 10.5 and 3762 ± 1932 ng/g in muscle and kidney, respectively. After 15 days of withdrawal, muscle penicillin G residues were quantifiable in only one treated hog (3.4 ng/g) but averaged 119 ± 199 ng/g in kidneys. Using a hypothetical tolerance of 50 ng/g and a natural log-linear depletion model, the withdrawal period required for penicillin depletion to 50 ng/g was 11 days for skeletal muscle and 47 days for kidney.