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Nucleozin Sale

(Synonyms: [4-(2-氯-4-硝基苯基)-1-哌嗪基](5-甲基-3-苯基-4-异噁唑基)-甲酮) 目录号 : GC15303

An antiviral

Nucleozin Chemical Structure

Cas No.:341001-38-5

规格 价格 库存 购买数量
25mg
¥515.00
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50mg
¥924.00
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200mg
¥2,132.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Nucleozin Description:EC50: Nucleozin inhibited infection of MDCK cells by the viruses influenza A/WSN/33, H3N2 (clinical isolate) and Vietnam/1194/04 (H5N1) with an EC50 of 0.069±0.003 μM, 0.16±0.01 μM and 0.33±0.04 μM in PRA, respectively [1].
Influenza nucleoprotein is the most abundantly expressed protein during the course of infection with multiple functionalities. In the presence of nucleozin, a potent antagonist of NP accumulation in the nucleus, NP failed to enter the nucleus leading to the virus death [1].
In vitro: Nucleozin was found to effectively inhibite viral growth even when added within 6 h after inoculation of the MDCK cells with the virus, indicating that the antiviral activities of nucleozin reside on post-entry and post-nuclear events, suggesting that multiple processes involving NP may be affected, although only the nuclear import process of NP can be readily observed [1]. However, another in-vitro study demonstrated that the primary target of nucleozin was the viral ribonucleoprotein, not NP, and this work also provided proof of the principle that IAV replication can be effectively inhibited by blocking cytoplasmic trafficking of the viral genome [2].
In vivo: With respect to in vivo antiviral efficacy, mice treated with nucleozin had a considerably higher survival rate after inoculation by influenza A virus H5N1 strain A/Vietnam/1194/04 than untreated controls. Without any treatment, all mice had died 7 d after inoculation. In the nucleozin-treated group, 50% of those receiving two doses of nucleozin (100 μl of 2.3 mg/ml nucleozin) per day for 7 d survived for more than 21 d. The animal study results show that nucleozin protected mice against hypervirulent influenza A H5N1 virus in vivo and thus has the potential to be developed into useful anti-influenza therapeutics [1].
Clinical trial: Up to now, nucleozin is still in the preclinical development stage.
Reference:
[1] Kao RY, Yang D, Lau LS, Tsui WH, Hu L, Dai J, Chan MP, Chan CM, Wang P, Zheng BJ, Sun J, Huang JD, Madar J, Chen G, Chen H, Guan Y, Yuen KY. Identification of influenza A nucleoprotein as an antiviral target. Nat Biotechnol. 2010;28(6):600-5.
[2] Amorim MJ, Kao RY, Digard P. Nucleozin targets cytoplasmic trafficking of viral ribonucleoprotein-Rab11 complexes in influenza A virus infection. J Virol. 2013;87(8):4694-703.

Chemical Properties

Cas No. 341001-38-5 SDF
别名 [4-(2-氯-4-硝基苯基)-1-哌嗪基](5-甲基-3-苯基-4-异噁唑基)-甲酮
化学名 [4-(2-chloro-4-nitrophenyl)piperazin-1-yl]-(5-methyl-3-phenyl-1,2-oxazol-4-yl)methanone
Canonical SMILES CC1=C(C(=NO1)C2=CC=CC=C2)C(=O)N3CCN(CC3)C4=C(C=C(C=C4)[N+](=O)[O-])Cl
分子式 C21H19ClN4O4 分子量 426.86
溶解度 ≥ 55.4 mg/mL in DMSO with ultrasonic, ≥ 3.28 mg/mL in EtOH with ultrasonic and warming 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
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1 mg 5 mg 10 mg
1 mM 2.3427 mL 11.7134 mL 23.4269 mL
5 mM 0.4685 mL 2.3427 mL 4.6854 mL
10 mM 0.2343 mL 1.1713 mL 2.3427 mL
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