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NSC232003 目录号 GC32721

规格 价格 库存 购买数量
10mM*1mL in Water
¥2,491.00
现货
1mg
¥1,339.00
现货
5mg
¥4,016.00
现货
50mg
¥20,081.00
现货
100mg
¥29,899.00
现货

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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 1905453-18-0 SDF Download SDF
别名 N/A
化学名 N/A
Canonical SMILES O=C1NC(/C(C=N1)=C(NO)/C)=O
分子式 C6H7N3O3 分子量 169.14
溶解度 H2O : 17 mg/mL (100.51 mM; Need ultrasonic and warming);DMSO : < 1 mg/mL (insoluble or slightly soluble) 储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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产品描述

NSC232003 is a highly potent and cell-permeable UHRF1 inhibitor, which inhibits DNA methylation in vitro and disrupts DNMT1/UHRF1 interactions at a cellular level.

NSC232003, a uracil derivative freely available by the NCI/DTP repository, provides a versatile lead for developing highly potent and cell-permeable UHRF1 inhibitors that will enable dissection of DNA methylation inheritance. NSC232003 is indeed an effective DNA methylation inhibitor and indicate that this particular nucleotide scaffold could provide a versatile basis for the design of potent UHRF1 inhibitors. NSC232003 is predicted to be partially deprotonated at pH 7, as the pKa of the more acidic imide nitrogen of the pyrimidine ring is a value of 7.6 in NSC232003. The DNMT1/UHRF1 interactions are significantly reduced after 4 h of incubation of U251 glioma cells with the most potent compound NSC232003, showing a 50% interaction inhibition at 15 μM as well as induction of global DNA cytosine demethylation as measured by ELISA[1].

[1]. Myrianthopoulos V, et al. Tandem virtual screening targeting the SRA domain of UHRF1 identifies a novel chemical tool modulating DNA methylation. Eur J Med Chem. 2016 May 23;114:390-6.