Nanofin (2,6-Lupetidine)
(Synonyms: 那诺芬; 2,6-Lupetidine) 目录号 : GC32508
Nanofin (2,6-Dimethylpiperidine, Lupetidine, Naniopinum) is a ganglion blocker alkaloid having nicotinic acetylcholine receptor antagonist action. It has antihypertensive effect used for mild to moderate hypertension.
Cas No.:504-03-0
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Nanofin (2,6-Dimethylpiperidine, Lupetidine, Naniopinum) is a ganglion blocker alkaloid having nicotinic acetylcholine receptor antagonist action. It has antihypertensive effect used for mild to moderate hypertension.
| Cas No. | 504-03-0 | SDF | |
| 别名 | 那诺芬; 2,6-Lupetidine | ||
| Canonical SMILES | CC1CCCC(C)N1 | ||
| 分子式 | C7H15N | 分子量 | 113.2 |
| 溶解度 | Soluble in DMSO | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 8.8339 mL | 44.1696 mL | 88.3392 mL |
| 5 mM | 1.7668 mL | 8.8339 mL | 17.6678 mL |
| 10 mM | 0.8834 mL | 4.417 mL | 8.8339 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Plasmonic bound states in the continuum to tailor light-matter coupling
Sci Adv 2022 Dec 9;8(49):eadd4816.PMID:36490330DOI:10.1126/sciadv.add4816.
Plasmon resonances play a pivotal role in enhancing light-matter interactions in nanophotonics, but their low-quality factors have hindered applications demanding high spectral selectivity. Here, we demonstrate the design and 3D laser nanoprinting of plasmonic Nanofin metasurfaces, which support symmetry-protected bound states in the continuum up to the fourth order. By breaking the nanofins' out-of-plane symmetry in parameter space, we achieve high-quality factor (up to 180) modes under normal incidence. The out-of-plane symmetry breaking can be fine-tuned by the nanofins' triangle angle, opening a pathway to precisely control the ratio of radiative to intrinsic losses. This enables access to the under-, critical, and over-coupled regimes, which we exploit for pixelated molecular sensing. We observe a strong dependence of the sensing performance on the coupling regime, demonstrating the importance of judicious tailoring of light-matter interactions. Our demonstration provides a metasurface platform for enhanced light-matter interaction with a wide range of applications.
Long short-term memory neural network for directly inverse design of Nanofin metasurface
Opt Lett 2022 Jul 1;47(13):3239-3242.PMID:35776595DOI:10.1364/OL.458453.
In this Letter, the neural network long short-term memory (LSTM) is used to quickly and accurately predict the polarization sensitivity of a Nanofin metasurface. In the forward prediction, we construct a deep neural network (DNN) with the same structure for comparison with LSTM. The test results show that LSTM has a higher accuracy and better robustness than DNN in similar cases. In the inverse design, we directly build an LSTM to reverse the design similar to the forward prediction network. By inputting the extinction ratio value in 8-12 µm, the inverse network can directly provide the unit cell geometry of the Nanofin metasurface. Compared with other methods used to inverse design photonic structures using deep learning, our method is more direct because no other networks are introduced.
Highly-efficient and angle-independent zero-order half waveplate at broad visible wavelength based on Au Nanofin array embedded in dielectric
Opt Express 2016 Apr 18;24(8):7966-76.PMID:27137238DOI:10.1364/OE.24.007966.
A Au Nanofin array embedded in SiO2 was designed and fabricated to achieve an achromatic half waveplate with high transmittance at visible wavelengths. On the basis of the waveguide theory of nanogaps and the Fresnel reflection theory, Nanofin array is calculated to have ideal properties for an achromatic half-waveplate in the visible band from 560 to 660 nm with the transmittance of around 50%. A Au Nanofin array with a height of 830 nm and a period of 400 nm was fabricated through a sidewall-deposition process and overcoating with spin on glass. The polarization microscopy results showed that both transmittance greater than 50% and retardation of 165° at broadband wavelengths ranging from 600 to 800 nm were simultaneously achieved. It was also demonstrated that retardation had little dependence on the incident angle.
Ultra-thin transmissive crystalline silicon high-contrast grating metasurfaces
Opt Express 2019 Oct 14;27(21):30931-30940.PMID:31684334DOI:10.1364/OE.27.030931.
Dielectric metasurfaces made from crystalline silicon, titanium dioxide, gallium nitride and silicon nitride have developed rapidly for applications in the visible wavelength regime. High performance metasurfaces typically require the realisation of subwavelength, high aspect ratio nanostructures, the fabrication of which can be challenging. Here, we propose and demonstrate the operation of high performance metasurfaces in ultra-thin (100 nm) crystalline silicon at the wavelength of 532 nm. Using optical beam analysis, we discuss fabrication complexity and show that our approach is more fabrication-tolerant than the Nanofin approach, which has so far produced the highest performance metasurfaces, but may be difficult to manufacture, especially when using nanoimprint lithography.
Facile fabrication of silver Nanofin array via electroless plating
Langmuir 2008 Apr 15;24(8):4205-8.PMID:18312009DOI:10.1021/la703512w.
The fabrication of metallic nanostructures is one of the main issues in nanotechnology. This article describes the fabrication of a silver Nanofin array by combining microlithography, electroless plating, and an etching technique. Fabricated Ag nanofins have a high aspect ratio (height/width = 10, width = 60 nm, height = 600 nm), and their widths and heights can be controlled by the period of electroless plating and the height of the original line pattern. An isolated Ag Nanofin was proven to show metallic electrical conductivity. The current process provides a rapid and shape-designable fabrication method of metallic nanostructures.