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N1-Acetylspermine (hydrochloride)

(Synonyms: N1-乙酰精胺三盐酸盐) 目录号 : GC44285

An acetyl derivative of spermine

N1-Acetylspermine (hydrochloride) Chemical Structure

Cas No.:77928-70-2

规格 价格 库存 购买数量
25mg
¥865.00
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50mg
¥1,615.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

N1-Acetylspermine is a monoacetylated derivative of spermine , an endogenous polyamine synthesized from spermidine , that displays lower Km and higher Vmax values than spermine, making it a better substrate of polyamine oxidase than the non-acetylated polyamine. [1] Spermine is required for eukaryotic cell growth and protein synthesis and is involved in the modulation of calcium-dependent immune processes. [2][3] N1-Acetylspermine has been used to study the uptake of the anticancer polyamine analog bleomycin-A5 by the human carnitine transporter SLC22A16.[4]

Reference:
[1]. Bolkenius, F.N., and Seiler, N. Acetylderivatives as intermediates in polyamine catabolism. International Journal of Biochemistry 13(3), 287-292 (1981).
[2]. Wallace, H.M., Fraser, A.V., and Hughes, A. A perspective of polyamine metabolism. Biochemistry Journal 376(Pt 1), 1-14 (2003).
[3]. Igarashi, K., and Kashiwagi, K. Polyamines: Mysterious modulators of cellular functions. Biochemical and Biophysical Research Communications 271(3), 559-564 (2000).
[4]. Aouida, M., Poulin, R., and Ramotar, D. The human carnitine transporter SLC22A16 mediates high affinity uptake of the anticancer polyamine analogue bleomycin-A5. The Journal of Biological Chemisty 285(9), 6275-6284 (2010).

Chemical Properties

Cas No. 77928-70-2 SDF
别名 N1-乙酰精胺三盐酸盐
化学名 N-[3-[[4-[(3-aminopropyl)amino]butyl]amino]propyl]-acetamide, trihydrochloride
Canonical SMILES CC(NCCCNCCCCNCCCN)=O.Cl.Cl.Cl
分子式 C12H28N4O•3HCl 分子量 353.8
溶解度 Water: 50 mg/ml 储存条件 Store at -20°C
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1 mM 2.8265 mL 14.1323 mL 28.2646 mL
5 mM 0.5653 mL 2.8265 mL 5.6529 mL
10 mM 0.2826 mL 1.4132 mL 2.8265 mL
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