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N-Isopropylnoratropine 目录号 GC10378

used in the synthesis of ipratropium, a muscarinic antagonist

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1mg
¥455.00
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5mg
¥2,054.00
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10mg
¥2,730.00
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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 22235-81-0 SDF
别名 NINA
化学名 (3-endo)-8-(1-methylethyl)-8-azabicyclo[3.2.1]oct-3-yl ester α-(hydroxymethyl)-benzeneacetic acid
Canonical SMILES O=C(C(CO)C1=CC=CC=C1)O[C@H]2C[C@H]3CC[C@H](N3C(C)C)C2
分子式 C19H27NO3 分子量 317.4
溶解度 ≤16mg/ml in ethanol;10mg/ml in DMSO;2mg/ml in dimethyl formamide 储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

产品描述

N-Isopropylnoratropine is a noratropine derivative and an intermediate in the production of ipratropium, an atropine-like bronchodilator drug via an anticholinergic pathway. N-Isopropylnoratropine is used to examine the stability of ipratropium [1].

Muscarinic acetylcholine receptors are acetylcholine receptors that form G protein-receptor complexes in the cell membranes of certain neurons and other cells.

N-Isopropylnoratropine is an intermediate in the production of ipratropium and used to examine the stability of ipratropium. Ipratropium exhibits broncholytic action by reducing the influence of cholinergic on the bronchial musculature. Ipratropium blocks muscarinic acetylcholine receptors and therefore promotes the degradation of cGMP. Ipratropium bromide (IB) is an anticholinergic bronchodilatory agent to treat chronic obstructive pulmonary disease. In anesthetized dogs, Ipratropium with 0.01 and 0.1 mg/ml constricted the airways to 22 +/- 2% and 20 +/- 3% of control, respectively, whereas larger concentrations caused bronchodilation [2]. In moderate asthmatic patients, Ipratropium bromide (IB) induced a significant shift of dose-response curve to inhalation of substance P (SP), suggesting that bronchoconstriction induced by SP could be attributed to a weak cholinergic activation [3].

References:
[1].  Kasawar GB, Farooqui M. Development and validation of a stability indicating RP-HPLC method for the simultaneous determination of related substances of albuterol sulfate and ipratropium bromide in nasal solution. J Pharm Biomed Anal. 2010 May 1;52(1):19-29.
[2].  Groeben H, Brown RH. Ipratropium decreases airway size in dogs by preferential M2 muscarinic receptor blockade in vivo. Anesthesiology. 1996 Oct;85(4):867-73.
[3].  Crimi N, Palermo F, Oliveri R, et al. Influence of antihistamine (astemizole) and anticholinergic drugs (ipratropium bromide) on bronchoconstriction induced by substance P. Ann Allergy. 1990 Aug;65(2):115-20.