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Maresin 1 目录号 GC40979

A 7,14-dihydroxy DHA formed from 14(S)-hydroperoxy DHA

规格 价格 库存 购买数量
10μg
¥806.00
现货
25μg
¥1,911.00
现货
50μg
¥3,627.00
现货
100μg
¥6,448.00
现货

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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 1268720-28-0 SDF Download SDF
别名 N/A
化学名 7R,14S-dihydroxy-4Z,8E,10E,12Z,16Z,19Z-docosahexaenoic acid
Canonical SMILES O[C@@H](/C=C/C=C/C=C\[C@@H](O)C/C=C\C/C=C\CC)C/C=C\CCC(O)=O
分子式 C22H32O4 分子量 360.5
溶解度 50mg/mL in ethanol 储存条件 Store at -80°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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产品描述

Docosahexaenoic acid (DHA) is an ω-3 fatty acid that is abundant in the brain and the retina and is known to be important in early development.[1],[2] Maresin 1 (7(R)-MaR1) is a 7,14-dihydroxy DHA formed from 14(S)-hydroperoxy DHA supplied exogenously to resident peritoneal mouse macrophages activated with zymosan A. It potently reduces infiltration of neutrophils into the mouse peritoneum in zymosan A-induced peritonitis when given intravenously (0.2 ng) and significantly increases phagocytosis of FITC-labeled zymosan A by isolated mouse macrophages (0.1-100 nM).[3] Analytical and biological comparisons of synthetic 7(R)-MaR1 with endogenously derived 7(R)-MaR1 have confirmed its identity as matching the natural product.[4]

Reference:
[1]. Su, H.-M. Mechanisms of n-3 fatty acid-mediated development and maintenance of learning memory performance. J. Nutr. Biochem. 21(5), 364-373 (2010).
[2]. Wu, T.C., and Chen, P.H. Health consequences of nutrition in childhood and early infancy. Pediatr. Neonatol. 50(4), 135-142 (2009).
[3]. Serhan, C.N., Yang, R., Martinod, K., et al. Maresins: Novel macrophage mediators with potent antiinflammatory and proresolving actions. J. Exp. Med. 206(1), 15-23 (2009).
[4]. Serhan, C. . (2007).