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LY2828360 Sale

目录号 : GC19231

A selective CB2 receptor agonist

LY2828360 Chemical Structure

Cas No.:1231220-79-3

规格 价格 库存 购买数量
5mg
¥495.00
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10mg
¥765.00
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25mg
¥1,530.00
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50mg
¥2,160.00
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100mg
¥3,522.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

LY2828360 is a slowly acting but efficacious G protein-biased cannabinoid (CB2) agonist, inhibiting cAMP accumulation and activating ERK1/2 signaling.

In WT mice, acute systemic administration of LY2828360 suppresses paclitaxel-induced mechanical and cold allodynia in a dose-dependent manner. LY2828360 produces time-dependent suppressions of paclitaxel-evoked mechanical and cold hypersensitivities and suppression of allodynia is maintained for at least 4.5 h post-injection relative to drug pre-injection levels. At 24 h post-injection, paclitaxel-induced mechanical allodynia has returned to drug pre-injection levels of hypersensitivity. Residual suppression of cold allodynia was absent by 72 h post LY2828360 treatment. Previously chronic administration of LY2828360 blocks the development of tolerance to the antiallodynic effects of morphine in WT but not in CB2KO mice. Chronic LY2828360 treatment suppresses paclitaxel-induced mechanical and cold allodynia in WT mice but not in CB2KO mice previously render tolerant to morphine[1].

References:
[1]. Lin X, et al. Slowly Signaling G Protein-Biased CB2 Cannabinoid Receptor Agonist LY2828360 Suppresses Neuropathic Pain with Sustained Efficacy and Attenuates Morphine Tolerance and Dependence. Mol Pharmacol. 2018 Feb;93(2):49-62.

Chemical Properties

Cas No. 1231220-79-3 SDF
Canonical SMILES CN1CCN(C2=C3N=C(C4=CC=CC=C4Cl)N(C5CCOCC5)C3=NC(C)=N2)CC1
分子式 C22H27ClN6O 分子量 426.94
溶解度 DMSO : 20.83 mg/mL (48.79 mM) 储存条件 Store at -20°C
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1 mg 5 mg 10 mg
1 mM 2.3422 mL 11.7112 mL 23.4225 mL
5 mM 0.4684 mL 2.3422 mL 4.6845 mL
10 mM 0.2342 mL 1.1711 mL 2.3422 mL
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