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Lufenuron Sale

(Synonyms: 虱螨脲) 目录号 : GC61832

Lufenuron 是一种亲脂性苯甲酰脲杀虫剂和几丁质合成抑制剂,可用于蚤和鱼虱的控制。Lufenuron 可抑制节肢动物的蜕皮。

Lufenuron Chemical Structure

Cas No.:103055-07-8

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥385.00
现货
100 mg
¥350.00
现货

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产品文档

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产品描述

Lufenuron is a lipophilic benzoylurea insecticide and a chitin synthesis inhibitor that can used for flea and fish lice control. Lufenuron inhibits moulting of arthropods[1][2].

References:
[1]. T C M Brock, et al. Toxicity of Sediment-Bound Lufenuron to Benthic Arthropods in Laboratory Bioassays. Aquat Toxicol. 2018 May;198:118-128.
[2]. Cai Wang, et al. Lufenuron Suppresses the Resistance of Formosan Subterranean Termites (Isoptera: Rhinotermitidae) to Entomopathogenic Bacteria. J Econ Entomol. 2013 Aug;106(4):1812-8.

Chemical Properties

Cas No. 103055-07-8 SDF
别名 虱螨脲
Canonical SMILES O=C(NC(NC1=CC(Cl)=C(OC(F)(F)C(F)C(F)(F)F)C=C1Cl)=O)C2=C(F)C=CC=C2F
分子式 C17H8Cl2F8N2O3 分子量 511.15
溶解度 DMSO : 250 mg/mL (489.09 mM) 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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1 mg 5 mg 10 mg
1 mM 1.9564 mL 9.7819 mL 19.5637 mL
5 mM 0.3913 mL 1.9564 mL 3.9127 mL
10 mM 0.1956 mL 0.9782 mL 1.9564 mL
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Research Update

Detection of Chitin Synthase Mutations in Lufenuron-Resistant Spodoptera frugiperda in China

Insects 2022 Oct 20;13(10):963.PMID:36292911DOI:10.3390/insects13100963.

Spodoptera frugiperda (J. E. Smith), is commonly known as fall armyworm, native to tropical and subtropical regions of America, is an important migratory agricultural pest. It is important to understand the resistance and internal mechanism of action of S. frugiperda against Lufenuron in China. Lufenuron is one of the main insecticides recommended for field use in China and has a broad prospect in the future. We conducted a bioassay using the diet-overlay method and found that the current S. frugiperda in China are still at a low level of resistance to Lufenuron. Secondly, we examined whether the mutation I1040M (I1042M in Plutella xylostella), associated with Lufenuron resistance, was produced in the field. And then we tested the expression of chitin synthase SfCHSA and SfCHSB in different tissues, and the changes of these two genes after Lufenuron induction. The results showed that there is still no mutation generation in China and there is a significant change in the expression of SfCHSA under the effect of Lufenuron. In conclusion, our study suggests that field S. frugiperda populations in 2019 and 2020 were less resistant to Lufenuron. In fall armyworm, chitin synthases included SfCHSA and SfCHSB genes, and after induction treatment with Lufenuron, the expression of the SfCHSA gene was significantly increased. In SfCHSA, no mutation has been detected in the site associated with Lufenuron resistance. Secondly, in S. frugiperda larvae, the SfCHSA gene was the highest in the head of the larvae, followed by the integument; while the SfCHSB gene was mainly concentrated in the midgut. Therefore, we believe that the SfCHSA gene plays a greater role in the resistance of S. frugiperda to Lufenuron than the SfCHSB gene. It is worth noting that understanding the level of resistance to Lufenuron in China, the main mechanism of action of Lufenuron on larvae, and the mechanism of resistance to Lufenuron in S. frugiperda will help in crop protection as well as in extending the life span of this insecticide.

Ameliorative effect of avocado oil against Lufenuron induced testicular damage and infertility in male rats

Andrologia 2022 Dec;54(11):e14580.PMID:36068645DOI:10.1111/and.14580.

Lufenuron is a benzoylurea pesticide that causes significant histological and histochemical damage in mammals. Avocado is a common food in the human diet that contains antioxidant and antitumor properties. In male rats, avocado oil's protection against lufenuron-induced reproductive deterioration, oxidative stress, and DNA damages was investigated. Twenty-eight mature male rats were selected and distributed into four groups: Group 1, control group were administered distilled water orally; Group 2 received 4 ml/kg avocado; Group 3 was given Lufenuron (1.6 mg/kg), and Group 4 was given avocado oil/Lufenuron. The findings show that Lufenuron treatment reduces reproductive hormone levels, sperm count, motility, viability and causes negative histopathological changes in testicular tissue, such as decreased epithelial height and increased luminal diameter degenerated spermatogenesis. Furthermore, Lufenuron reduced the content of antioxidant enzymes while increasing the level of malondialdehyde, nitric oxide and corresponding DNA damage. Results showed that Lufenuron is associated with testicular function impairment, which leads to infertility. Treatment with avocado oil improved reproductive hormone secretions, enzymatic activity, histological and DNA damage parameters in testis tissues, reducing the negative effects of Lufenuron, proving that it may have a therapeutic role against lufenuron-mediated testicular toxicity.

Lufenuron suppresses the resistance of Formosan subterranean termites (Isoptera: Rhinotermitidae) to entomopathogenic bacteria

J Econ Entomol 2013 Aug;106(4):1812-8.PMID:24020297DOI:10.1603/ec13068.

Pesticides can negatively affect insect immunity. Although studies show that Formosan subterranean termites, Coptotermes formosanus Shiraki, are resistant to microbial infections, the effects of pesticides on disease resistance is not well studied. In this study, C. formosanus previously fed Lufenuron was exposed to each of the three entomopathogenic bacteria, Pseudomonas aeruginosa (Schroeter) Migula, Serratia marcescens Bizio, and Bacillus thuringiensis Berliner subsp. israelensis. We found that termite mortality was significantly higher and synergistic in the combination of Lufenuron and P. aeruginosa compared with treatment of Lufenuron or P. aeruginosa alone. Other bacteria and Lufenuron combinations were not quite as effective. Interestingly, only in treatments without Lufenuron did termites show carcass-burying behavior. The results indicate that Lufenuron, a chitin synthesis inhibitor, can suppress Formosan subterranean termite resistance to P. aeruginosa. Possible suppression mechanisms are discussed.

Lufenuron can be transferred by gravid Aedes aegypti females to breeding sites and can affect their fertility, fecundity and blood intake capacity

Parasit Vectors 2020 May 15;13(1):257.PMID:32414396DOI:10.1186/s13071-020-04130-1.

Background: Aedes aegypti (L.) is the main vector of dengue, yellow fever, Zika and chikungunya viruses. A new method for controlling this mosquito has been developed based on the possibility that wild adult mosquitoes exposed to artificial resting sites contaminated with a larvicide, can disseminate it to larval breeding sites, is named "auto-dissemination". The present study was undertaken to evaluate if a chitin synthesis inhibitor like Lufenuron can be disseminated to larval breeding sites and prevent adult emergence and also if forced contact of Ae. aegypti females with treated surfaces can affect its fertility, fecundity, and blood intake capacity. Methods: Larval susceptibility to Lufenuron was measured through EI50 and EI90. On the other hand, gravid females were exposed by tarsal contact to lufenuron-treated papers, we used the WHO susceptibility test kit tube to line the papers, and 1, 3 or 5 females for the transference. We also evaluated if the exposure of female mosquitoes to lufenuron-treated papers (0.4 and 1 mg a.i./cm2) has an effect on their fertility, fecundity or in the ability to feed on blood. In each assay 12-15 female mosquitoes were exposed to Lufenuron for 1 h, 24 h before blood meal (BBM) or 24 h after a blood meal (ABM). Results: Lufenuron proved to be very active against Ae. aegypti larvae with an EI50 of 0.164 ppb and EI90 of 0.81 ppb. We also found that Lufenuron can be transferred by females from treated surfaces to clean containers causing the inhibition of emergence of the larvae (between 30 and 50%). This effect was dependent on the concentration applied on the paper and the number of females added to each cage. Conclusions: This study introduces an innovation by first exploring the possibility that an insect growth regulator (IGR) belonging to the group of benzoylphenyl ureas, such as Lufenuron, can be transferred by gravid females to breeding sites and that at the same time can have an effect on fertility, fecundity and blood intake capacity of adult mosquitoes.

Effects of Lufenuron treatments on the growth and development of Spodoptera frugiperda (Lepidoptera: Noctuidae)

Comp Biochem Physiol C Toxicol Pharmacol 2023 Jan;263:109499.PMID:36336329DOI:10.1016/j.cbpc.2022.109499.

Lufenuron is an effective benzoylurea insecticide that inhibits the synthesis of chitin and regulates the growth of insects. However, little is known about the effects of Lufenuron treatment on the development of Spodoptera frugiperda (J. E. Smith). In this study, we assessed the toxicity of Lufenuron on S. frugiperda and evaluated the effects of Lufenuron treatment on the growth and development of S. frugiperda. The results showed that Lufenuron exhibits high insecticidal activity against S. frugiperda, with the LC50 value of 0.99 mg L-1. Lufenuron treatments can significantly prolong the larval developmental duration and reduce the rates of pupation and emergence. To further explore the underlying mechanism of this observation, the expression profiles of the chitin synthase gene (SfCHS) and chitinase gene (SfCHT), two key enzyme genes involved in the molting of S. frugiperda, were determined after exposure to Lufenuron for 96 h. The results of qRT-PCR demonstrated that Lufenuron treatments can significantly reduce the expression of SfCHT, while the expression of SfCHS remained relatively stable. Furthermore, we found that Lufenuron strongly interacted with chitinase (SfCHT) (-10.8 kcal/mol) and chitin synthase (SfCHS) (R1: -9.7 kcal/mol; R2: -10.2 kcal/mol). Our results indicated that Lufenuron has significant effects on the development of S. frugiperda that might be attributed to the differential expression of SfCHT and SfCHS.