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LMP744 hydrochloride (MJ-III65 hydrochloride) Sale

(Synonyms: MJ-III65 hydrochloride; NSC706744 hydrochloride) 目录号 : GC33202

LMP744 hydrochloride (MJ-III65 hydrochloride) (MJ-III65 hydrochloride) 是一种 DNA 嵌入剂和拓扑异构酶 I (Top1) 抑制剂,具有抗肿瘤活性。

LMP744 hydrochloride (MJ-III65 hydrochloride) Chemical Structure

Cas No.:308246-57-3

规格 价格 库存 购买数量
1mg
¥962.00
现货
5mg
¥2,610.00
现货
10mg
¥4,050.00
现货
20mg 待询 待询

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

LMP744 hydrochloride (MJ-III65 hydrochloride) is a DNA intercalator and Topoisomerase (Top1) inhibitor with antitumor activity[1].

The GI50 value of LMP744 (MJ-III-65) for NCI60 cells is 0.1 μM[1].LMP744 (0.1-5 μM, 3 days) induces dose-dependent accumulation of cells in the S and G2 phases of the cell cycle[1].|| Cell Cytotoxicity Assay[1]||Cell Line:|P388 and P388 Top1-deficient murine leukemia cells|Concentration:|0.1-100 μM|Incubation Time:|3 days|Result:|induced dose-dependent accumulation of cells in the S and G2 phases of the cell cycle

MJ-III-65 (10-50 mg/kg) administered i.v. push once a week for 4 weeks in nude mice moderately actives against human A253 and FaDu tumor xenografts without significant toxicity[2].|| Animal Model:|Athymic nude mice (nu/nu, female, 20-25 g, 8-12 weeks old) transplanted with A253 and FaDu human head and neck xenografts[2].|Dosage:|10, 25, or 50 mg/kg/week, 4 weeks|Administration:|i.v. push via tail vein|Result:|moderately actived against human A253 and FaDu tumor xenografts without significant toxicity

[1]. Antony S, et al. Bisindenoisoquinoline bis-1,3-{( 5,6-dihydro-5,11-diketo-11H-indeno [1,2-c]isoquinoline)-6-propylamino}propane bis(trifluoroacetate) (NSC 727357), a DNA intercalator and topoisomerase inhibitor with antitumor activity. Mol Pharmacol. 2006 Sep;70(3):1109-20. [2]. Antony S, et al. Cellular topoisomerase I inhibition and antiproliferative activity by MJ-III-65 (NSC 706744), an indenoisoquinoline topoisomerase I poison. Mol Pharmacol. 2005 Feb;67(2):523-30.

Chemical Properties

Cas No. 308246-57-3 SDF
别名 MJ-III65 hydrochloride; NSC706744 hydrochloride
Canonical SMILES OCCNCCCN1C2=C(C(C3=CC(OCO4)=C4C=C23)=O)C5=CC(OC)=C(OC)C=C5C1=O.Cl
分子式 C24H25ClN2O7 分子量 488.92
溶解度 DMSO : 5.56 mg/mL (11.37 mM) 储存条件 Store at -20°C
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1 mg 5 mg 10 mg
1 mM 2.0453 mL 10.2266 mL 20.4532 mL
5 mM 0.4091 mL 2.0453 mL 4.0906 mL
10 mM 0.2045 mL 1.0227 mL 2.0453 mL
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