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(±)-Lisofylline

(Synonyms: 利索茶碱,BL 194,CT-1501R,LSF) 目录号 : GC13662

A potent inhibitor of phosphatidic acid generation

(±)-Lisofylline Chemical Structure

Cas No.:6493-06-7

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10mg
¥1,016.00
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25mg
¥1,273.00
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50mg
¥2,410.00
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100mg
¥3,893.00
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产品描述

(±)-Lisofylline is an anti-inflammatory agent.

Anti-inflammatory refers to the property of a agent or treatment reducing inflammation or swelling. Anti-inflammatory drugs make up about half of analgesics, remedying pain by reducing inflammation as opposed to opioids.

In vitro: (±)-Lisofylline is a potent anti-inflammatory agent in which only the (-) optical isomer is biologically active. (±)-Lisofylline was found to inhibit the generation of phosphatidic acid from cytokine-activated lysophosphatidic acyl transferase. (±)-Lisofylline could also suppress the production of the proinflammatory cytokine IFN-γ, inhibit IL-12-mediated STAT-4 activation, as well as enhance glucose-stimulated β-cell insulin secretion [1].

In vivo: In a previous study, lisofylline was administered to female non-obese diabetic mice for 3 weeks. Cytokines and blood glucose concentrations were monitored. Histology and immunohistochemistry were also carried out in pancreatic sections. Results showed that lisofylline was able to suppress IFN-γ production, reduce the onset of insulitis and diabetes, and inhibit diabetes [1].

Clinical trial: A clinical trial has been conducted to determine whether the administration of lisofylline would decrease mortality in patients with acute lung injury (ALI) or acute respiratory distress syndrome (ARDS). However, this trial was stopped for futility at the first scheduled interim analysis. It was found that there was no significant difference between groups in the number of patients who had died at 28 days and there was no significant difference between the lisofylline and placebo groups in terms of ventilator-free days, infection-related deaths, resolution of organ failures, or development of serious infection [2].

References:
[1] Yang, Z. D.,Chen, M.,Wu, R., et al. The anti-inflammatory compound lisofylline prevents type I diabetes in non-obese diabetic mice. Diabetologia 45, 1307-1314 (2002).
[2] No authors listed.  Randomized, placebo-controlled trial of lisofylline for early treatment of acute lung injury and acute respiratory distress syndrome. Crit Care Med. 2002 Jan;30(1):1-6.

Chemical Properties

Cas No. 6493-06-7 SDF
别名 利索茶碱,BL 194,CT-1501R,LSF
化学名 3,7-dihydro-1-(5-hydroxyhexyl)-3,7-dimethyl-1H-purine-2,6-dione
Canonical SMILES CC(O)CCCCn1c(=O)c2n(C)cnc2n(C)c1=O
分子式 C13H20N4O3 分子量 280.3
溶解度 ≤2mg/ml in ethanol;10mg/ml in DMSO;10mg/ml in dimethyl formamide 储存条件 Store at -20°C
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1 mM 3.5676 mL 17.838 mL 35.6761 mL
5 mM 0.7135 mL 3.5676 mL 7.1352 mL
10 mM 0.3568 mL 1.7838 mL 3.5676 mL
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