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Linezolid D3 Sale

(Synonyms: 利奈唑胺-D3,PNU-100766-d3) 目录号 : GC60993

An internal standard for the quantification of linezolid

Linezolid D3 Chemical Structure

Cas No.:1127120-38-0

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1mg
¥1,980.00
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5mg
¥4,770.00
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Sample solution is provided at 25 µL, 10mM.

产品文档

Quality Control & SDS

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产品描述

Linezolid-d3 is intended for use as an internal standard for the quantification of linezolid by GC- or LC-MS. Linezolid is a synthetic oxazolidinone antibiotic with activity against a wide range of Gram-positive bacteria, including resistant strains of several species, such as methicillin-resistant S. aureus (MRSA), penicillin-resistant pneumococci, vancomycin-resistant enterococci, various anaerobic bacteria, and several mycobacteria and streptococci (MICs = 2-4 mg/ml).1 Linezolid inhibits protein synthesis by binding to domain V of the 23S ribosomal RNA of the 50S subunit of bacterial ribosomes. In vivo, linezolid (50 mg/kg) reduces pulmonary MRSA load in spontaneously breathing and mechanically ventilated rabbits.2 Formulations containing linezolid have been used to treat MRSA infections.

1.Ager, S., and Gould, K.Clinical update on linezolid in the treatment of gram-positive bacterial infectionsInfect. Drug Resist.587-102(2012) 2.Pauchard, L.A., Blot, M., Bruyere, T., et al.Linezolid and atorvastatin impact on pneumonia caused by Staphyloccocus aureus in rabbits with or without mechanical ventilationPLoS One12(11)e0187187(2017)

Chemical Properties

Cas No. 1127120-38-0 SDF
别名 利奈唑胺-D3,PNU-100766-d3
Canonical SMILES O=C(O[C@H]1CNC(C([2H])([2H])[2H])=O)N(C1)C2=CC(F)=C(N3CCOCC3)C=C2
分子式 C16H17D3FN3O4 分子量 340.36
溶解度 DMF: 30 mg/ml,DMSO: 20 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): 0.1 mg/ml 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.9381 mL 14.6903 mL 29.3807 mL
5 mM 0.5876 mL 2.9381 mL 5.8761 mL
10 mM 0.2938 mL 1.469 mL 2.9381 mL
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