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Leukotriene C4-d5 methyl ester Sale

(Synonyms: LTC4d5 methyl ester) 目录号 : GC47558

A neuropeptide with diverse biological activities

Leukotriene C4-d5 methyl ester Chemical Structure

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25 μg
¥2,312.00
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50 μg
¥4,403.00
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100 μg
¥8,325.00
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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Leukotriene C4-d5 (LTC4-d5) methyl ester contains five deuterium atoms at the 19, 19', 20, 20 and 20 positions. It is intended for use as an internal standard for the quantification of LTC4 methyl ester by GC- or LC-mass spectrometry. LTC4 is the parent cysteinyl-leukotriene produced by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4. LTC4 is produced by neutrophils, macrophages, and mast cells, and by transcellular metabolism in platelets.1 It is one of the constituents of slow-reacting substance of anaphylaxis and exhibits potent smooth muscle contracting activity.2 LTC4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute allergic hypersensitivity.3,4 The concentration of LTC4 required to produce marked contractions of lung parenchymal strips and isolated tracheal rings is about 1 nM.4 LTC4 methyl ester is a more lipid soluble form of LTC4. The biological activity of LTC4 methyl ester has not been reported.

1.Maclouf, J.A., and Murphy, R.C.Transcellular metabolism of neutrophil-derived leukotriene A4 by human platelets. A potential cellular source of leukotriene C4J. Biol. Chem.263(1)174-181(1988) 2.Piper, P.J.Formation and actions of leukotrienesPhysiol. Rev.64(2)744-761(1984) 3.Samuelsson, B.Leukotrienes: Mediators of immediate hypersensitivity reactions and inflammationScience220(4597)568-575(1983) 4.Lefer, A.M.Leukotrienes as mediators of ischemia and shockBiochem. Pharmacol.35(2)123-127(1986)

Chemical Properties

Cas No. N/A SDF
别名 LTC4d5 methyl ester
Canonical SMILES O=C(OC)CCC[C@H](O)[C@H](SCC(C(NCC(O)=O)=O)NC(CCC(N)C(O)=O)=O)/C=C/C=C/C=C\C/C=C\CCCC([2H])([2H])C([2H])([2H])[2H]
分子式 C31H44D5N3O9S 分子量 644.8
溶解度 DMF: 50 mg/ml,DMSO: 50 mg/ml,Ethanol: 1 mg/ml,Ethanol:H20 (95:5): 2 mg/ml,PBS (pH 7.2): 0.1 mg/ml 储存条件 Store at -80°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 1.5509 mL 7.7543 mL 15.5087 mL
5 mM 0.3102 mL 1.5509 mL 3.1017 mL
10 mM 0.1551 mL 0.7754 mL 1.5509 mL
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