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Lanopepden (GSK 1322322) Sale

(Synonyms: GSK 1322322) 目录号 : GC32311

Lanopepden (GSK 1322322) (GSK 1322322) 是一种肽去甲酰基酶抑制剂,对金黄色葡萄球菌菌株具有活性,对 ATCC 29213 和 ATCC 25923 菌株的 MIC 分别为 1 和 1 mg/L。

Lanopepden (GSK 1322322) Chemical Structure

Cas No.:1152107-25-9

规格 价格 库存 购买数量
250mg 待询 待询
500mg 待询 待询

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产品描述

Lanopepden (GSK 1322322) is a peptide deformylase inhibitor active against Staphylococcus aureus strains with MICs of 1 and 1 mg/L for ATCC 29213 and ATCC 25923 strain, respectively[1].

[1]. Peyrusson F, et al. Cellular pharmacokinetics and intracellular activity of the novel peptide deformylase inhibitor GSK1322322 against Staphylococcus aureus laboratory and clinical strains with various resistance phenotypes: studies with human THP-1 monocytes and J774 murine macrophages. Antimicrob Agents Chemother. 2015 Sep;59(9):5747-60.

Chemical Properties

Cas No. 1152107-25-9 SDF
别名 GSK 1322322
Canonical SMILES FC1=C(N2CCN(CCOC3)[C@@]3([H])C2)N=C(C)N=C1NNC([C@H](CC4CCCC4)CN(C=O)O)=O
分子式 C22H34FN7O4 分子量 479.55
溶解度 Soluble in DMSO 储存条件 Store at -20°C
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溶解性数据

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1 mM 2.0853 mL 10.4264 mL 20.8529 mL
5 mM 0.4171 mL 2.0853 mL 4.1706 mL
10 mM 0.2085 mL 1.0426 mL 2.0853 mL
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Research Update

Peptide deformylase: a new target in antibacterial, antimalarial and anticancer drug discovery

Curr Med Chem 2015;22(2):214-36.PMID:25174923DOI:10.2174/0929867321666140826115734

Peptide deformylase (PDF) is a class of metalloenzyme responsible for catalyzing the removal of the N-formyl group from N-terminal methionine following translation. PDF inhibitors are moving into new phase of drug development. Initially, PDF was considered as an important target in antibacterial drug discovery; however genome database searches have revealed PDF-like sequences in parasites (P. falciparum) and human, widening the utility of this target in antimalarial and anticancer drug discovery along with antibacterial. Using structural and mechanistic information together with high throughput screening, several types of chemical classes of PDF inhibitors with improved efficacy and specificity have been identified. Various drugs like, GSK-1322322 (Phase II), BB-83698 (Phase I), and LBM-415 (Phase I) have entered into clinical developments. Developments in the field have prompted us to review the current aspects of PDFs, especially their structures, different classes of PDF inhibitors, and molecular modeling studies. In nut shell, this review enlightens PDF as a versatile target along with its inhibitors and future perspectives of different PDF inhibitors.