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(Synonyms: H2N-Lys-Ala-Gly-Gln-Val-Val-Thr-Ile-Trp-OH ) 目录号 : GP10016

Lys-Ala-Gly-Gln-Val-Val-Thr-Ile-Trp

Lamin fragment Chemical Structure

规格 价格 库存 购买数量
1mg
¥378.00
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5mg
¥1,176.00
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10mg
¥1,911.00
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25mg
¥2,541.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Lamin fragment has a peptide sequence of Lys-Ala-Gly-Gln-Val-Val-Thr-Ile-Trp.

The lamins are type V intermediate filaments which can be categorized as either A-type (lamin A, C) or B-type (lamin B1, B2) according to homology in sequence, biochemical properties and cellular localization during the cell cycle. Lamin polypeptides have an almost complete ǁ-helical conformation with multiple ǁ-helical domains separated by non-ǁ-helical linkers that are highly conserved in length and amino acid sequence.

Nuclear lamins are intermediate filament-type proteins that are the major building blocks of the nuclear lamina, a fibrous proteinaceous meshwork underlying the inner nuclear membrane. Lamins can also be localized in the nuclear interior, in a diffuse or spotted patter. Lamins also play roles in DNA replication, chromatin organization, spatial arrangement of nuclear pore complexes, nuclear growth, and anchorage of nuclear envelope proteins.

References:
1. The Cell: A Molecular Approach, Cooper & Hausman. 5th Edition. Pg. 357
2. Ayelet Margalit, Sylvia Vlcek, Yozef Gruenbaum, Roland Foisner (2005). Breaking and Making of the Nuclear Envelope. Journal of Cellular Biochemistry 95, 454-465
3. Bruce Alberts, et al. Molecular Biology of the Cell (4th edition). Garland Science 676-677
4. Geoffrey M. Cooper, Robert E. Hausman. The Cell, A Molecular Approach (4th edition). Sinauer Associates 356-360
5. Goldman et al.(2002). "Nuclear lamins: building blocks of nuclear architecture". Genes and Development 16,533-547
6. Joanna M. Bridger, Nicole Foeger, Ian R. Kill, Harald Herrmann (2007). The Nuclear Lamina: both a structural framework and a platform for genome organization. FEBS Journal 274, 1354-1361
7. Nico Stuurman, Susanne Heins, Ueli Aebi (1998). Nuclear Lamins: Their Structure, Assembly and Interactions. Journal of Structural Biology 122, 42-46
8. Tripathi K, Muralikrishna B and Parnaik VK (2009) Differential dynamics and stability of lamin A rod domain mutants IJIB, 5(1), 1-8
9. Yozef Gruenbaum, Katherine L. Wilson, Amnon Harel, Michal Goldberg, Merav Cohen (2000). Nuclear Lamins - Structural Proteins with fundamental functions. Journal of Structural Biology129, 313-323

Chemical Properties

Cas No. SDF
别名 H2N-Lys-Ala-Gly-Gln-Val-Val-Thr-Ile-Trp-OH
Canonical SMILES NC(CCCCN)C(NC(C)C(NCC(NC(CCC(N)=O)C(NC(C(C)C)C(NC(C(C)C)C(NC(C(C)O)C(NC(C(C)CC)C(NC(CC1=CNC2=C1C=CC=C2)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O
分子式 C47H76N12O12 分子量 1001.18
溶解度 ≥ 100.1mg/mL in DMSO 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

制备储备液
1 mg 5 mg 10 mg
1 mM 0.9988 mL 4.9941 mL 9.9882 mL
5 mM 0.1998 mL 0.9988 mL 1.9976 mL
10 mM 0.0999 mL 0.4994 mL 0.9988 mL
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