Home>>Kallidin (380-389) (human, porcine, bovine) (trifluoroacetate salt)

Kallidin (380-389) (human, porcine, bovine) (trifluoroacetate salt)

(Synonyms: KRPPGFSPFR, Lys-BK, Lysine Bradykinin) 目录号 : GC47524

具有多种生物活性的神经肽

Kallidin (380-389) (human, porcine, bovine) (trifluoroacetate salt) Chemical Structure

规格 价格 库存 购买数量
5 mg
¥1,131.00
现货
10 mg
¥2,038.00
现货
25 mg
¥4,814.00
现货
50 mg
¥8,479.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Kallidin (380-389) is a short-lived kinin peptide involved in inflammation and pain.1 It binds to bradykinin B2 (IC50 = 0.63 nM) and B1 receptors (Ki = 3.23 nM) and acts as an agonist.1,2,3 It is formed in tissue, including the brain, via cleavage of low molecular weight kininogen (LMWK) by kallikrein serine proteases released in response to injury or inflammation and can be converted into bradykinin.1 Kallidin levels in interstitial muscle are increased in women with work-related trapezius myalgia.4

1.Dray, A.Kinins and their receptors in hyperalgesiaCan. J. Physiol. Pharmacol.75(6)704-712(1997) 2.Bastian, S., Loillier, B., Paquet, J.L., et al.Stable expression of human kinin B1 receptor in 293 cells: Pharmacological and functional characterizationBr. J. Pharmacol.122(2)393-399(1997) 3.Hess, J.F., Borkowski, J.A., Macneil, T., et al.Differential pharmacology of cloned human and mouse B2 bradykinin receptorsMol. Pharmacol.45(1)1-8(1994) 4.Gerdle, B., Hilgenfeldt, U., Larsson, B., et al.Bradykinin and kallidin levels in the trapezius muscle in patients with work-related trapezius myalgia, in patients with whiplash associated pain, and in healthy controls - a microdialysis study of womenPain139(3)578-587(2008)

Chemical Properties

Cas No. N/A SDF
别名 KRPPGFSPFR, Lys-BK, Lysine Bradykinin
Canonical SMILES NCCCC[C@H](N)C(N[C@@H](CCCNC(N)=N)C(N1[C@H](C(N2CCC[C@H]2C(NCC(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CO)C(N4[C@H](C(N[C@H](C(N[C@H](C(O)=O)CCCNC(N)=N)=O)CC5=CC=CC=C5)=O)CCC4)=O)=O)=O)=O)=O)CCC1)=O)=O.OC(C(F)(F)F)=O
分子式 C56H85N17O12.XCF3COOH 分子量 1188.4
溶解度 DMSO: slightly soluble,PBS (pH 7.2): 10 mg/ml 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 0.8415 mL 4.2073 mL 8.4147 mL
5 mM 0.1683 mL 0.8415 mL 1.6829 mL
10 mM 0.0841 mL 0.4207 mL 0.8415 mL
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