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IgG light chain variable region [Homo sapiens]/IgM/kappa antibody [Mus musculus] Sale

(Synonyms: H2N-Thr-Asp-Phe-Thr-Leu-Thr-Ile-OH ) 目录号 : GP10044

IgG light chain region

IgG light chain variable region [Homo sapiens]/IgM/kappa antibody [Mus musculus] Chemical Structure

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1mg
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5mg
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25mg
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产品描述

IgG has four forms, provides the majority of antibody-based immunity against invading pathogens.[1] The only antibody capable of crossing the placenta to give passive immunity to the fetus. IgM is expressed on the surface of B cells (monomer) and in a secreted form (pentamer) with very high avidity. Eliminates pathogens in the early stages of B cell mediated (humoral) immunity before there is sufficient IgG.[2] The immunoglobulin light chain is the small polypeptide subunit of an antibody ( immunoglobulin). Kappa (NJ) chain, one of the two types of light chain in mammals, is encoded by the immunoglobulin kappa locus (IGK@) on chromosome 2. Only V and J segments are found in Ig light chains.[3]

The approximate length of a light chain protein is from 211 to 217 amino acids.[4]

If the lymph node or similar tissue is reactive, or otherwise benign, it should possess a mixture of kappa positive and lambda positive cells. If, however, one type of light chain is significantly more common than the other, the cells are likely all derived from a small clonal population, which may indicate a malignant condition, such as B-cell lymphoma.[5]

Increased levels of free Ig light chains have also been detected in various inflammatory diseases. Very recent studies have shown that Ig light chains not only activate mast cells but also dorsal root ganglia (Rijnierse, 2009)) and neutrophils (Braber and Thio (2012)), expanding their possible role as mediators in inflammatory disease.

References:
1. Pier GB, Lyczak JB, Wetzler LM (2004). Immunology, Infection, and Immunity. ASM Press. ISBN 1-55581-246-5.
2. Geisberger R, Lamers M, Achatz G (2006). "The riddle of the dual expression of IgM and IgD". Immunology 118 (4): 060526021554006 -- . doi: 10.1111 / j. 1365-2567 . 2006.02386.x. PMC 1782314. PMID 16895553
3. Nemazee D (2006). "Receptor editing in lymphocyte development and central tolerance". Nat Rev Immunol 6 (10): 728-740. doi:10.1038/nri1939.PMID 16998507
4. Janeway CA, Jr. et al. (2001). Immunobiology. (5th ed.). Garland Publishing. (electronic full text via NCBI Bookshelf) ISBN 0-8153-3642-X.
5. Leong, Anthony S-Y; Cooper, Kumarason; Leong, F Joel W-M (2003). Manual of Diagnostic Cytology (2 ed.). Greenwich Medical Media, Ltd.. pp. 283-285.ISBN 1-84110-100-1.

Chemical Properties

Cas No. SDF
别名 H2N-Thr-Asp-Phe-Thr-Leu-Thr-Ile-OH
Canonical SMILES C[C@@H](O)[C@H](N)C(NC(CC(O)=O)C(NC(CC1=CC=CC=C1)C(N[C@@H]([C@@H](O)C)C(NC(CC(C)C)C(N[C@H](C(N[C@H]([C@@H](C)CC)C(O)=O)=O)[C@@H](O)C)=O)=O)=O)=O)=O
分子式 C37H59N7O13 分子量 809.9
溶解度 ≥ 81mg/mL in DMSO 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 1.2347 mL 6.1736 mL 12.3472 mL
5 mM 0.2469 mL 1.2347 mL 2.4694 mL
10 mM 0.1235 mL 0.6174 mL 1.2347 mL
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