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Hexamethonium Bromide Sale

(Synonyms: 六甲溴铵) 目录号 : GC15178

A nondepolarizing neuromuscular blocking agent

Hexamethonium Bromide Chemical Structure

Cas No.:55-97-0

规格 价格 库存 购买数量
50mg
¥494.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Hexamethonium Bromide is a non-depolarising ganglionic blocker, a nicotinic nACh (NN) receptor antagonist.Target: nAChRHexamethonium Bromide is a non-depolarising ganglionic blocker, a nicotinic nACh receptor antagonist that acts in autonomic ganglia by binding mostly in or on the NN receptor, and not the acetylcholine binding site itself. It does not have any effect on the muscarinic acetylcholine receptors (mAChR) located on target organs of the parasympathetic nervous system but acts as antagonist at the nicotinic acetylcholine receptors located in sympathetic and parasympathetic ganglia (NN). Hexamethonium Bromide is a nicotinic acetyl choline receptor antagonist. Induces apoptosis and inhibits the stimulatory effect of nicotine on endothelial cell DNA synthesis and proliferation. Hexamethonium bromide hydrate is an inhibitor of AChR α3 [1-3].

References:
[1]. Maneckjee, R. and J.D. Minna, Opioids induce while nicotine suppresses apoptosis in human lung cancer cells. Cell Growth Differ, 1994. 5(10): p. 1033-40.
[2]. Sanchez-Fortun, S., F. Sanz, and M.V. Barahona, Acute toxicity of several organophosphorous insecticides and protection by cholinergic antagonists and 2-PAM on Artemia salina larvae. Arch Environ Contam Toxicol, 1996. 31(3): p. 391-8.
[3]. Villablanca, A.C., Nicotine stimulates DNA synthesis and proliferation in vascular endothelial cells in vitro. J Appl Physiol (1985), 1998. 84(6): p. 2089-98.

Chemical Properties

Cas No. 55-97-0 SDF
别名 六甲溴铵
化学名 trimethyl-[6-(trimethylazaniumyl)hexyl]azanium;dibromide
Canonical SMILES C[N+](C)(C)CCCCCC[N+](C)(C)C.[Br-].[Br-]
分子式 C12H30N2.2Br 分子量 362.19
溶解度 ≥ 36.6mg/mL in Water, ≥ 36.3mg/mL in DMSO with gentle warming, ≥ 36.2mg/mL in EtOH with gentle warming 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.761 mL 13.8049 mL 27.6098 mL
5 mM 0.5522 mL 2.761 mL 5.522 mL
10 mM 0.2761 mL 1.3805 mL 2.761 mL
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