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HBcAg [Hepatitis B virus] (18-27)

目录号 GP10047

Indicator of active viral replication

规格 价格 库存 购买数量
1mg
¥389.00
现货
5mg
¥1,050.00
现货
10mg
¥1,943.00
现货
25mg
¥2,636.00
现货

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Sample solution is provided at 25 µL, 10mM.

质量管理

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产品描述

HBcAg (core antigen) is a hepatitis B viral protein1,2. It is an indicator of active viral replication; this means the person infected with Hepatitis B can likely transmit the virus on to another person.HBeAg is the extracellular form of HBcAg, hence why the presence of both are markers of viral replication, and antibodies to these antigens are markers of a decline in replication.Multiple protein products can be produced from the same DNA sequence. When "ORF Core" and "Pre C" are translated together, the result is "HBeAg".Whereas HBcAg is considered "particulate", "HBeAg" is considered "nonparticulate" or "secretory".Both HBeAg and HBcAg are made from the same reading frame, but HBeAg is secreted from cells and accumulates in serum as an immunologically distinct soluble antigen. HBeAg is secreted and found in the serum of patients and serves as a marker of active replication in chronic hepatitis. Although the function of HBeAg is not clearly understood, one study demonstrated that it downregulated Toll-like receptor 2 expression on hepatocytes and monocytes leading to a decrease in cytokine expression. HBeAg is dispensable for replication, as mutant viruses with defects in the pre-C region are both infectious and pathogenic3.

References:
1. Kimura T, Rokuhara A, Matsumoto A, et al. (May 2003). "New enzyme immunoassay for detection of hepatitis B virus core antigen (HBcAg) and relation between levels of HBcAg and HBV DNA". J. Clin. Microbiol. 41 (5): 1901-6.
2. Cao T, Meuleman P, Desombere I, S?llberg M, Leroux-Roels G (December 2001). "In vivo inhibition of anti-hepatitis B virus core antigen (HBcAg) immunoglobulin G production by HBcAg-specific CD4(+) Th1-type T-cell clones in a hu-PBL-NOD/SCID mouse model". J. Virol. 75 (23): 11449-56.
3. Mandell,Douglas, and Bennett's Principles and Practice of Infectious Diseases. 7th ed. page 2062

Chemical Properties

Cas No. N/A SDF
别名 H-Phe-Leu-Pro-Ser-Asp-Phe-Phe-Pro-Ser-Val-OH
化学名 N/A
Canonical SMILES N[C@H](C(N[C@H](C(N1[C@@H](CCC1)C(N[C@@H](CO)C(N[C@H](C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CC3=CC=CC=C3)C(N4[C@@H](CCC4)C(N[C@H](C(N[C@H](C(O)=O)C(C)C)=O)CO)=O)=O)=O)=O)CC(O)=O)=O)=O)=O)CC(C)C)=O)CC5=CC=CC=C5
分子式 C58H78N10O15 分子量 1155.3
溶解度 ≥ 115.5mg/mL in DMSO 储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

动物体内配方计算器 (澄清溶液)

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