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GSK'872 目录号 GC19175

规格 价格 库存 购买数量
5mg
¥588.00
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10mg
¥987.00
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25mg
¥1,848.00
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50mg
¥3,350.00
现货
100mg
¥5,324.00
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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 1346546-69-7 SDF Download SDF
别名 N/A
化学名 N/A
Canonical SMILES O=S(C1=CC=C2N=CC=C(NC3=CC=C(SC=N4)C4=C3)C2=C1)(C(C)C)=O
分子式 C19H17N3O2S2 分子量 383.49
溶解度 DMSO : ≥ 100 mg/mL (260.76 mM) 储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

产品描述

GSK’872 is a RIPK3 inhibitor, which binds RIP3 kinase domain with an IC50 of 1.8 nM, and inhibits kinase activity with an IC50 of 1.3 nM.

GSK’872 blocks necroptosis in mouse cells. RIP3i GSK’872 inhibits TLR3- or DAI-induced death, two RIP1-independent pathways of necroptosis[1]. Pretreatment with GSK’872 (GSK-872) confers significant protection to primary hepatocytes. However, RIPK1 inhibition (by Nec1) does not impart any protection to primary hepatocytes[2].

References:
[1]. Mandal P, et al. RIP3 induces apoptosis independent of pronecrotic kinase activity. Mol Cell. 2014 Nov 20;56(4):481-95.
[2]. Arora D, et al. Deltamethrin induced RIPK3-mediated caspase-independent non-apoptotic cell death in rat primary hepatocytes. Biochem Biophys Res Commun. 2016 Oct 14;479(2):217-223.