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GRL0617 目录号 GC39172

A SARS-CoV and SARS-CoV-2 PLpro inhibitor

规格 价格 库存 购买数量
5mg
¥3,150.00
现货
10mg
¥5,850.00
现货
50mg
¥18,000.00
现货
100mg
¥27,000.00
现货
200mg 询价 询价
500mg 询价 询价

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Sample solution is provided at 25 µL, 10mM.

质量管理

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Chemical Properties

Cas No. 1093070-16-6 SDF Download SDF
别名 N/A
化学名 N/A
Canonical SMILES O=C(N[C@@H](C1=C2C=CC=CC2=CC=C1)C)C3=CC(N)=CC=C3C
分子式 C20H20N2O 分子量 304.39
溶解度 DMSO: 125 mg/mL (410.66 mM) 储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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产品描述

GRL0617 is a potent, selective and competitive noncovalent inhibitor of severe acute respiratory syndrome (SARS-CoV) papain-like protease (PLpro)/deubiquitinase, with an IC50 of 0.6 μM, and with a Ki of 0.49 μM[1].

[1]. Ratia K, et al. A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication. Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16119-24.