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Glycoursodeoxycholic acid (Ursodeoxycholylglycine) Sale

(Synonyms: 甘氨熊胆酸,Ursodeoxycholylglycine) 目录号 : GC33687

A glycine-conjugated form of ursodeoxycholic acid

Glycoursodeoxycholic acid (Ursodeoxycholylglycine) Chemical Structure

Cas No.:64480-66-6

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥491.00
现货
10mg
¥446.00
现货
50mg
¥714.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

Glycoursodeoxycholic acid (GUDCA) is a glycine-conjugated form of the secondary bile acid ursodeoxycholic acid .1,2 It has antioxidant effects in vitro in Barrett’s esophagus cells and primary cultured rat neurons.3,4 GUDCA reduces the levels of inflammatory cytokines and prevents cell death induced by unconjugated bilirubin in an astroglial cell model of neonatal hyperbilirubinemia.5 Oral administration of GUDCA (500 mg/kg per day) decreases the severity of symptoms and increases the amount of A. muciniphila, a bacterial species commonly decreased in patients with inflammatory bowel disease (IBD), in a mouse model of colitis.2

1.Lefebvre, P., Cariou, B., Lien, F., et al.Role of bile acids and bile acid receptors in metabolic regulationPhysiol. Rev.89(1)147-191(2009) 2.Van den Bossche, L., Hindryckx, P., Devisscher, L., et al.Ursodeoxycholic acid and its taurine- or glycine-conjugated species reduce colitogenic dysbiosis and equally suppress experimental colitis in miceAppl. Environ. Microbiol.83(7)e02766-02716(2017) 3.Goldman, A., Condon, A., Adler, E., et al.Protective effects of glycoursodeoxycholic acid in Barrett's esophagus cellsDis. Esophagus23(2)83-93(2010) 4.Brito, M.A., Lima, S., Fernandes, A., et al.Bilirubin injury to neurons: Contribution of oxidative stress and rescue by glycoursodeoxycholic acidNeurotoxicology29(2)259-269(2008) 5.Fernandes, A., Vaz, A.R., Falcao, A.S., et al.Glycoursodeoxycholic acid and interleukin-10 modulate the reactivity of rat cortical astrocytes to unconjugated bilirubinJ. Neuropathol. Exp. Neurol.66(9)789-798(2007)

Chemical Properties

Cas No. 64480-66-6 SDF
别名 甘氨熊胆酸,Ursodeoxycholylglycine
Canonical SMILES O=C(O)CNC(CC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])[C@@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)=O
分子式 C26H43NO5 分子量 449.62
溶解度 DMF: 10 mg/ml,DMSO: 10 mg/ml,DMSO:PBS(pH 7.2) (1:4): 0.2 mg/ml,Ethanol: 1 mg 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.2241 mL 11.1205 mL 22.241 mL
5 mM 0.4448 mL 2.2241 mL 4.4482 mL
10 mM 0.2224 mL 1.1121 mL 2.2241 mL
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