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GF 15 Sale

目录号 : GC33334

GF15是有效的中心体聚集(centrosomalclustering)抑制剂,可抑制肿瘤细胞的生长。

GF 15 Chemical Structure

Cas No.:888042-13-5

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Sample solution is provided at 25 µL, 10mM.

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实验参考方法

Cell experiment:

Hela cells are treated with GF 15 (0, 0.25, 0.5, 0.75, 1, 1.25 μM) for 24 and/or 48 hours. Cell viability is examined using the MTT assay[1].

Animal experiment:

Mice[1]Beige-nude Xid mice are inoculated s.c. in the right flank with 3×106 OPM2 or HT29 cells. When a tumor is measurable, mice are assigned to a GF 15 treatment group (20, 100 mg/kg) or the control group for 0-20 days. Tumor burden is measured every alternating day using an electronic caliper.

References:

[1]. Raab MS, et al. GF-15, a novel inhibitor of centrosomal clustering, suppresses tumor cell growth in vitro and in vivo. Cancer Res. 2012 Oct 15;72(20):5374-85.

产品描述

GF 15 is a potent inhibitor of centrosomal clustering in tumor cells.

GF 15 leads to multipolar mitosis induction with an EC50 of 900 nM. GF 15 exhibits potent cytotoxicity in a concentration-dependent manner against a broad spectrum of tumor cell types including colon, cervix, glioblastoma, pancreas, leukemia, and myeloma-derived cell lines with IC50s of 1-5 μM[1].

Treatment of mouse xenograft models of human colon cancer and multiple myeloma with GF 15 results in tumor growth inhibition and significantly prolonged survival[1].

[1]. Raab MS, et al. GF-15, a novel inhibitor of centrosomal clustering, suppresses tumor cell growth in vitro and in vivo. Cancer Res. 2012 Oct 15;72(20):5374-85.

Chemical Properties

Cas No. 888042-13-5 SDF
Canonical SMILES O=C1[C@]2(C(OCC3=CC=CC=C3)=CC(C[C@H]2C)=O)OC4=C(Cl)C(OC)=CC(OC)=C14
分子式 C23H21ClO6 分子量 428.86
溶解度 Soluble in DMSO 储存条件 Store at -20°C
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.3318 mL 11.6588 mL 23.3176 mL
5 mM 0.4664 mL 2.3318 mL 4.6635 mL
10 mM 0.2332 mL 1.1659 mL 2.3318 mL
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