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2-Oxosuccinic acid Sale

(Synonyms: 草酰乙酸; 2-Oxosuccinic acid) 目录号 : GC38276

An α-keto acid

2-Oxosuccinic acid Chemical Structure

Cas No.:328-42-7

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥347.00
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500mg
¥315.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Oxaloacetic acid is an α-keto acid and a key component of cellular metabolism in its conjugate base form, oxaloacetate.1,2,3 Oxaloacetate reacts with acetyl-coenzyme A and water to form citrate in the first step of the citric acid cycle and is regenerated by oxidation of L-malate in the final step.2 It is an intermediate in gluconeogenesis that is formed in mitochondria via carboxylation of pyruvate and subsequently decarboxylated and phosphorylated to form phosphoenolpyruvate.3 It can be converted to aspartate via addition of an amino group from glutamate.1 Oxaloacetate (30 μmol/min per 100 g for 30 minutes, i.v.) reduces blood glutamate levels, severity of neurological dysfunction, and brain edema in a rat model of closed head injury.4

1.Berg, J.M., Tymoczko, J.L., and Stryer, L.Amino acids are made from intermediates of the citric acid cycle and other major pathwaysBiochemistry(2002) 2.Berg, J.M., Tymoczko, J.L., and Stryer, L.The citric acid cycle oxidizes two-carbon unitsBiochemistry(2020) 3.Berg, J.M., Tymoczko, J.L., and Stryer, L.Glucose can be synthesized from noncarbohydrate precursorsBiochemistry(2002) 4.Zlotnik, A., Gurevich, B., Tkachov, S., et al.Brain neuroprotection by scavenging blood glutamateExp. Neurol.203(1)213-220(2007)

Chemical Properties

Cas No. 328-42-7 SDF
别名 草酰乙酸; 2-Oxosuccinic acid
Canonical SMILES O=C(O)C(CC(O)=O)=O
分子式 C4H4O5 分子量 132.07
溶解度 Water: ≥ 100 mg/mL (757.17 mM); DMSO: ≥ 100 mg/mL (757.17 mM) 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 7.5717 mL 37.8587 mL 75.7174 mL
5 mM 1.5143 mL 7.5717 mL 15.1435 mL
10 mM 0.7572 mL 3.7859 mL 7.5717 mL
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第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
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