Androsin
(Synonyms: 草夹竹桃苷) 目录号 : GC35342
A phenol glucoside with diverse biological activities
Cas No.:531-28-2
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Androsin is a phenol glucoside that has been found in P. kurroa and has diverse biological activities.1,2,3 It is active against the bacteria S. aureus, S. epidermidis, P. aeruginosa, E. cloacae, K. pneumoniae, and E. coli (MICs = 0.6, 0.68, 0.97, 0.85, 1, and 1.08 mg/ml, respectively) and the fungi C. albicans, C. tropicalis, and C. glabrata (MICs = 1.85, 1.7, and 1.65 mg/ml, respectively).3 Androsin (10 mg/kg) inhibits bronchial obstruction in a guinea pig model of asthma induced by ovalbumin or platelet-activating factor (PAF).2
1.Stuppner, H., and Wagner, H.Minor iridoid and phenol glycosides of Picrorhiza kurrooaPlanta Med.55(5)467-469(1988) 2.Dorsch, W., Stuppner, H., Wagner, H., et al.Antiasthmatic effects of Picrorhiza kurroa: Androsin prevents allergen- and PAF-induced bronchial obstruction in guinea pigsInt. Arch. Allergy Appl. Immunol.95(2-3)128-133(1991) 3.Zajdel, S.M., Graikou, K., Sotiroudis, G., et al.Two new iridoids from selected Penstemon species - antimicrobial activityNat. Prod. Res.27(24)2263-2271(2013)
| Cas No. | 531-28-2 | SDF | |
| 别名 | 草夹竹桃苷 | ||
| Canonical SMILES | CC(C1=CC=C(O[C@H]2[C@@H]([C@H]([C@@H]([C@@H](CO)O2)O)O)O)C(OC)=C1)=O | ||
| 分子式 | C15H20O8 | 分子量 | 328.31 |
| 溶解度 | Soluble in DMSO | 储存条件 | 4°C, protect from light |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.0459 mL | 15.2295 mL | 30.459 mL |
| 5 mM | 0.6092 mL | 3.0459 mL | 6.0918 mL |
| 10 mM | 0.3046 mL | 1.523 mL | 3.0459 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Antiasthmatic effects of Picrorhiza kurroa: Androsin prevents allergen- and PAF-induced bronchial obstruction in guinea pigs
Int Arch Allergy Appl Immunol 1991;95(2-3):128-33.PMID:1718906DOI:10.1159/000235416.
In the Ayurvedic medicine, Picrorhiza kurroa Royle ex Benth. is used for the treatment of liver and lung diseases. Using different chemical and pharmacological methods, we could identify the phenol glycoside Androsin as active compound preventing allergen and platelet-activating factor induced bronchial obstruction in guinea pigs in vivo (10 mg/kg p.o.; 1 h prior to the inhalation challenge). Histamine release from human polymorphonuclear leukocytes in vitro was inhibited by other compounds yet to be identified.
Phenolic glycosides from Pyrola japonica
Chem Pharm Bull (Tokyo) 2004 Jun;52(6):714-7.PMID:15187393DOI:10.1248/cpb.52.714.
Five new phenolic glycosides, 2-beta-D-glucopyranosyloxy-5-hydroxyphenylacetic acid methyl ester (4), 4-hydroxy-2-[3-hydroxy-3-methylbutyl]-5-methylphenyl beta-D-glucopyranoside (5), 4-hydroxy-2-[(E)-4-hydroxy-3-methyl-2-butenyl]-5-methylphenyl beta-D-glucopyranoside (7), 4-hydroxy-2-[(2E,6Z)-8-beta-D-glucopyranosyloxy-3,7-dimethylocta-2,6-dien-1-yl]-5-methylphenyl beta-D-glucopyranoside (8), and 2,7-dimethyl-1,4-dihydronaphthalene-5,8-diol 5-O-beta-D-xylopyranosyl(1-->6)-beta-D-glucopyranoside (10), were isolated from the whole plants of Pyrola japonica (Pyrolaceae), together with Androsin, (-)-syringaresinol glucoside, homoarbutin, pirolatin, hyperin, monotropein and chimaphilin.
Minor Iridoid and Phenol Glycosides of Picrorhiza kurrooa
Planta Med 1989 Oct;55(5):467-9.PMID:17262460DOI:10.1055/s-2006-962066.
From the roots of PICRORHIZA KURROOA a new iridoid glycoside, 6-feruloylcatalpol has been isolated, along with veronicoside and minecoside and two phenol glucosides, picein and Androsin.
Antioxidative phenylethanoid and phenolic glycosides from Picrorhiza scrophulariiflora
Chem Pharm Bull (Tokyo) 2004 May;52(5):615-7.PMID:15133218DOI:10.1248/cpb.52.615.
One new phenylenthanoid glycoside, scroside D (2), was isolated from the roots of Picrorhiza scrophulariiflora (Scrophulariaceae), together with nine known phenylethanoid and phenolic glycosides: 2-(3,4-dihydroxyphenyl)-ethyl-O-beta-D-glucopyranoside (1), 2-(3-hydroxy-4-methoxyphenyl)-ethyl-O-beta-D-glucopyranosyl (1-->3)-beta-D-glucopyranoside (3), scroside B (4), hemiphroside A (5), plantainoside D (6), scroside A (7), Androsin (8), piceoside (9), and 6-O-feruloyl-beta-D-glucopyranoside (10). The structures of these compounds were elucidated using spectroscopic methods. The antioxidative activities of these isolated compounds were evaluated based on their scavenging effects on hydroxyl radicals and superoxide anion radicals, respectively. Compounds 1, 2, and 6 showed potent antioxidative effects as those of ascorbic acid and the structure-activity relationship is discussed.
Counter-current chromatographic method for preparative scale isolation of picrosides from traditional Chinese medicine Picrorhiza scrophulariiflora
J Sep Sci 2011 Aug;34(15):1910-6.PMID:21721121DOI:10.1002/jssc.201100025.
Apocynin, Androsin, together with picroside I, II and III from crude extracts of Picrorhiza scrophulariiflora were isolated by means of high-speed counter-current chromatography (CCC) combining elution-extrusion (EE) and cycling-elution (CE) approach. The EECCC took full advantages of the liquid nature of the stationary phase for a complete sample recovery and extended the solute hydrophobicity window, while CECCC showed its unique advantage in achieving effective separation of special compounds through preventing stationary phase loss. In the present work, the biphasic liquid system composed of n-hexane/ethyl acetate/methanol/water (1:2:1:2, v/v/v/v) was used for separation of apocynin and Androsin, ethyl acetate/n-butanol/water/formic acid (4:1:5:0.005, v/v/v/v) for picroside I, II and III. However, due to the extremely similar K values (K1 /K2 ≈1.2), picroside I and III were always eluted together by several biphasic solvent systems. In this case, the CECCC exhibited great superiority and baseline separated in the sixth cycle using ethyl acetate/water (1:1, v/v) as biphasic liquid system. Each fraction was analyzed by UPLC-UV and ESI-MS analysis, and identified by comparing with the data of reference substances. Compared with classical elution, the combination of EE and CE approach exhibits strong separation efficiency and great potential to be a high-throughput separation technique in the case of complex samples.