Home>>Signaling Pathways>> Proteases>> HIV Integrase>>(±)-BI-D
(±)-BI-D 目录号 GC34961

(_plusmn_)-BI-D是HIV整合酶(integrase)变构抑制剂,作用于整合酶与LEDGF/p75结合部位。

规格 价格 库存 购买数量
10mM*1mL in DMSO
¥2,810.00
现货
2mg
¥2,100.00
现货
5mg
¥3,150.00
现货
10mg
¥4,500.00
现货
50mg
¥13,500.00
现货
100mg
¥18,900.00
现货
200mg 询价 询价
500mg 询价 询价

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Sample solution is provided at 25 µL, 10mM.

质量管理

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Chemical Properties

Cas No. 1416258-16-6 SDF Download SDF
别名 N/A
化学名 N/A
Canonical SMILES OC(C(OC(C)(C)C)C1=C(C(C=CC=C2)=C2N=C1C)C3=CC(CCCO4)=C4C=C3)=O
分子式 C25H27NO4 分子量 405.49
溶解度 DMSO: ≥ 100 mg/mL (246.62 mM) 储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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产品描述

(±)-BI-D is a potent ALLINI(An allosteric IN inhibitor) that binds integrase at the LEDGF/p75 binding site.IC50 value: 2.4-2.9 μM(HIV-Luc infection of WT and Hdgfrp2 KO cells) [1]Target: integrase inhibitorin vitro: Approximately 2.4-2.9 μM of BI-D was required to inhibit 50% of HIV-Luc infection of WT and Hdgfrp2 KO cells, while the IC50 decreased dramatically, to 160-200 nM, in Psip1 and double-KO cells [1].

[1]. Wang H, et al. HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor. Nucleic Acids Res. 2012 Dec;40(22):115 [2]. Fader LD, et al. Minimizing the Contribution of Enterohepatic Recirculation to Clearance in Rat for the NCINI Class of Inhibitors of HIV. ACS Med Chem Lett. 2014 Apr 16;5(6):711-6.