Flurbiprofen-d3
(Synonyms: 氟比洛芬-D3氘代物,dl-Flurbiprofen-d3) 目录号 : GC47366
An internal standard for the quantification of flurbiprofen
Cas No.:1185133-81-6
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Flurbiprofen-d3 is intended for use as an internal standard for the quantification of flurbiprofen by GC- or LC-MS. Flurbiprofen is a non-selective COX inhibitor (IC50s = 0.04 and 0.51 μM for COX-1 and COX-2, respectively).1 In vivo, flurbiprofen (0.3-4.8 mg/kg, p.o.) reduces carrageenan-induced hind paw edema and yeast-induced fever in rats.2 Flurbiprofen reduces plasma fibrinogen levels and arthritic score in a rat model of adjuvant-induced arthritis. It also reduces tumor weight and prostaglandin production and increases survival in a WHT-NC mouse xenograft model when administered at a dose of 5 mg/kg.3 Formulations containing flurbiprofen have been used to manage pain and inflammation associated with arthritis.
1.Barnett, J., Chow, J., Ives, D., et al.Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus systemBiochim Biophys. Acta.1209(1)130-139(1994) 2.Glenn, E.M., Rohloff, N., Bowman, B.J., et al.The pharmacology of 2-(2-fluoro-4-biphenylyl)propionic acid (flurbiprofen). A potent non-steroidal anti-inflammatory drugAgents Actions3(4)210-216(1973) 3.Bennett, A., Houghton, J., Leaper, D.J., et al.Tumour growth and response to treatment: Beneficial effect of the prostaglandin synthesis inhibitor flurbiprofen [proceedings]Br. J. Pharmacol.63(2)356P-357P(1978)
| Cas No. | 1185133-81-6 | SDF | |
| 别名 | 氟比洛芬-D3氘代物,dl-Flurbiprofen-d3 | ||
| Canonical SMILES | FC1=CC(C(C([2H])([2H])[2H])C(O)=O)=CC=C1C2=CC=CC=C2 | ||
| 分子式 | C15H10D3FO2 | 分子量 | 247.3 |
| 溶解度 | DMF: 25 mg/ml,DMSO: 10 mg/ml,Ethanol: 25 mg/ml,PBS (pH 7.2): 0.9 mg/ml | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 4.0437 mL | 20.2184 mL | 40.4367 mL |
| 5 mM | 0.8087 mL | 4.0437 mL | 8.0873 mL |
| 10 mM | 0.4044 mL | 2.0218 mL | 4.0437 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。